Found 780 with Last Name = 'gough' and Initial = 'pj' TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline
Curated by ChEMBL
GlaxoSmithKline
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Competitive inhibition of human RIP1 (1 to 375 residues) in presence of increasing ATP by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 2nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 15.8nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 25.1nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 25.1nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 31.6nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 31.6nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 39.8nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 50.1nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 50.1nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...More data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 63.1nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 79.4nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serumMore data for this Ligand-Target Pair
Affinity DataKi: 79.4nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serumMore data for this Ligand-Target Pair
Affinity DataKi: 79.4nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serumMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serumMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serumMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serumMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataKi: 158nMAssay Description:Binding affinity to CCR4 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 251nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...More data for this Ligand-Target Pair
