Compile Data Set for Download or QSAR
Found 10 with Last Name = 'houghton' and Initial = 'pj'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Burnham Institute

LigandPNGBDBM15186(4-(5-{[(5E)-2-amino-3,7-dicyano-4,6-dimethyl-5H-cy...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/mole IC50: 2.60E+3nMpH: 7.5 T: 2°CAssay Description:The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W4ZPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Burnham Institute

LigandPNGBDBM15187(3-[(2E)-3-(1H-1,3-benzodiazol-2-yl)prop-2-enoyl]-6...)copy SMILEScopy InChI
Affinity DataKi:  3.90E+3nM ΔG°:  -30.9kJ/mole IC50: 4.50E+3nMpH: 7.5 T: 2°CAssay Description:The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W4ZPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Burnham Institute

LigandPNGBDBM15188(5-{5-[(1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)me...)copy SMILEScopy InChI
Affinity DataKi:  2.08E+4nM ΔG°:  -26.7kJ/mole IC50: 2.51E+4nMpH: 7.5 T: 2°CAssay Description:The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W4ZPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)copy SMILEScopy InChI
Affinity DataIC50: 176nMAssay Description:TP_TRANSPORTER: drug resistance(Imatinib mesylate) in BCRP-expressing SaoS2 cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50241571(CHEMBL485981 | buddledin A)copy SMILEScopy InChI
Affinity DataIC50: 5.04E+4nMAssay Description:Inhibition of 5-lipoxygenase in Wistar rat peritoneal leukocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1JCWPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Burnham Institute

LigandPNGBDBM15190(3-(5-{[(5E)-2-amino-3,7-dicyano-4,6-dimethyl-5H-cy...)copy SMILEScopy InChI
Affinity DataIC50: 6.02E+4nMpH: 7.5 T: 2°CAssay Description:The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W4ZPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM23415(5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataIC50: 1.23E+5nMAssay Description:Inhibition of 5-lipoxygenase in Wistar rat peritoneal leukocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1JCWPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Burnham Institute

LigandPNGBDBM15189(4-(5-{[(5E)-2-amino-3,7-dicyano-4,6-dimethyl-5H-cy...)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+5nMpH: 7.5 T: 2°CAssay Description:The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W4ZPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50250796(CHEMBL465682 | buddledin C)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of 5-lipoxygenase in Wistar rat peritoneal leukocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1JCWPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50241572(CHEMBL519046 | buddledin B)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of 5-lipoxygenase in Wistar rat peritoneal leukocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1JCWPubMed