Compile Data Set for Download or QSAR
Found 90 with Last Name = 'ngo' and Initial = 'pl'
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313895(3-(5-(2-amino-1-phenylpropan-2-yl)furan-2-yl)-N-((...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313896(3-(5-((R)-2-amino-1-phenylpropan-2-yl)oxazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135936(3-(6-Amino-pyridin-3-yl)-2-(1-butyl-1H-imidazol-4-...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313896(3-(5-((R)-2-amino-1-phenylpropan-2-yl)oxazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)copy SMILEScopy InChI
Affinity DataIC50: 8.20nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16041(3-{5-[(1R)-1-amino-1-methyl-2-phenylethyl]-1,3,4-o...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetCarboxypeptidase M(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of purified Carboxypeptidase M (CPM) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16040((3-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-5-(N-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313895(3-(5-(2-amino-1-phenylpropan-2-yl)furan-2-yl)-N-((...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135935(3-(6-Amino-pyridin-3-yl)-2-(1-benzyl-1H-imidazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135940(3-(6-Amino-pyridin-3-yl)-2-(1-ethyl-1H-imidazol-4-...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135937(3-(6-Amino-pyridin-3-yl)-2-(1-methyl-1H-imidazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135938(3-(6-Amino-pyridin-3-yl)-2-(1-isopropyl-1H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16041(3-{5-[(1R)-1-amino-1-methyl-2-phenylethyl]-1,3,4-o...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25363(4-(cyclohexylamino)-1-(3-fluorophenyl)-8-{[3-(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 110nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6PVKPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105305(CHEMBL90698 | N-(4-{3-((R)-sec-Butyl)-3-[(S)-2-(3,...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16039(3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-N-[(1...)copy SMILEScopy InChI
Affinity DataIC50: 138nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16040((3-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-5-(N-...)copy SMILEScopy InChI
Affinity DataIC50: 163nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16036(2-Amino-2-benzyl-3-hydroxypropyl-3-({[(1R)-1-(4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 193nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313897(3-((R)-1-(4-fluorophenyl)ethylcarbamoyl)-5-(N-meth...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16039(3-[(2-amino-2-methyl-3-phenylpropoxy)methyl]-N-[(1...)copy SMILEScopy InChI
Affinity DataIC50: 344nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121929((phenylmethyl)butanedioic acid | 2-benzylbutanedio...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313901(3-((2-amino-2-benzyl-3-fluoropropoxy)methyl)-N-((R...)copy SMILEScopy InChI
Affinity DataIC50: 432nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313889(3-(((R)-2-amino-2-benzyl-3-hydroxypropoxy)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 580nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313897(3-((R)-1-(4-fluorophenyl)ethylcarbamoyl)-5-(N-meth...)copy SMILEScopy InChI
Affinity DataIC50: 684nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105328(CHEMBL313645 | N-(4-{3-[(S)-2-(3,4-Dichloro-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313894(3-(5-((R)-2-amino-1-phenylpropan-2-yl)-1H-1,2,4-tr...)copy SMILEScopy InChI
Affinity DataIC50: 822nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313900(3-((2-amino-2-benzyl-3,3-difluoropropoxy)methyl)-N...)copy SMILEScopy InChI
Affinity DataIC50: 925nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313901(3-((2-amino-2-benzyl-3-fluoropropoxy)methyl)-N-((R...)copy SMILEScopy InChI
Affinity DataIC50: 997nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105336((2S,5S)-2-[(S)-(3,4-Dichloro-phenyl)-hydroxy-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135933(3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105338((S)-2-[(S)-(3,4-Dichloro-phenyl)-hydroxy-methyl]-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105311(CHEMBL90682 | N-(4-{3-[(S)-2-(3,4-Dichloro-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313889(3-(((R)-2-amino-2-benzyl-3-hydroxypropoxy)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121929((phenylmethyl)butanedioic acid | 2-benzylbutanedio...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100009(2-(1H-Imidazol-4-yl)-3-phenyl-propionic acid | 2-(...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313903(3-(((R)-2-amino-3-phenylpropoxy)methyl)-N-((R)-1-(...)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+3nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313909(3-(3-((R)-2-amino-1-phenylpropan-2-yl)-1,2,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313910(3-(5-((R)-2-amino-1-phenylpropan-2-yl)-1,2,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105321(CHEMBL88513 | N-(4-{3-Cyclopropyl-3-[(S)-2-(3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25361(N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313888(3-(((S)-2-amino-2-benzyl-3-hydroxypropylamino)meth...)copy SMILEScopy InChI
Affinity DataIC50: 3.47E+3nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25362(4-(cyclohexylamino)-1-(3-fluorophenyl)-8-[(3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6PVKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313894(3-(5-((R)-2-amino-1-phenylpropan-2-yl)-1H-1,2,4-tr...)copy SMILEScopy InChI
Affinity DataIC50: 4.74E+3nMpH: 7.2Assay Description:Inhibition of human BACE1 expressed in mouse fibroblast cells assessed as inhibition of secreted APPbeta-NF production at pH 7.2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313898(3-((2-amino-2-methyl-3-phenylpropylamino)methyl)-N...)copy SMILEScopy InChI
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44JXPubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135938(3-(6-Amino-pyridin-3-yl)-2-(1-isopropyl-1H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 6.40E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1J0ZPubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105352(CHEMBL90864 | N-(4-{3-[(S)-2-(3,4-Dichloro-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+3nMAssay Description:Binding affinity of the compound against platelet thrombin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1WJ1PubMed
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