Compile Data Set for Download or QSAR
Found 652 with Last Name = 'blaney' and Initial = 'pm'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50394918(CHEMBL2165504)copy SMILEScopy InChI
Affinity DataKi:  6.60E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50394917(CHEMBL2165505)copy SMILEScopy InChI
Affinity DataKi:  7.80E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394916(CHEMBL2165506)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392144(CHEMBL2152774)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50394910(CHEMBL2165512)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394913(CHEMBL2165509)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394920(CHEMBL2165672)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394921(CHEMBL2165671)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394908(CHEMBL2165666)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392145(CHEMBL2152775)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50394893(CHEMBL2165502)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394909(CHEMBL2165513)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394903(CHEMBL2165492)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392141(CHEMBL2152771)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50394897(CHEMBL2165498)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392139(CHEMBL2152769)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50394918(CHEMBL2165504)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50394919(CHEMBL2165503)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394915(CHEMBL2165507)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394911(CHEMBL2165511)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392138(CHEMBL2152768)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50392146(CHEMBL2152776)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
LigandPNGBDBM50394895(CHEMBL2165500)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394896(CHEMBL2165499)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390498((�) 3-(6-methyl-2-{[4-(trifluoromethoxy)phe...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390499(US10442772, Example 2-162-2 | US9957235, 2-162-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
LigandPNGBDBM50394894(CHEMBL2165501)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394900(CHEMBL2165495)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50394914(CHEMBL2165508)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
LigandPNGBDBM50392140(CHEMBL2152770)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59J8PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM415800(US10442772, Example 2-170 | US10442772, Example 2-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390662(US10442772, Example 2-247-2 | US9957235, 2-247-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390662(US10442772, Example 2-247-2 | US9957235, 2-247-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390522(US9957235, 2-170 | US9957235, 2-170-1 | US9957235,...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390499(US10442772, Example 2-162-2 | US9957235, 2-162-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390522(US9957235, 2-170 | US9957235, 2-170-1 | US9957235,...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390525(US10442772, Example 2-171-2 | US9957235, 2-171 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390528(US10442772, Example 2-175-2 | US9957235, 2-172 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
LigandPNGBDBM50394917(CHEMBL2165505)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390499(US10442772, Example 2-162-2 | US9957235, 2-162-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390543(US10442772, Example 2-170-2 | US9957235, 2-177 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390525(US10442772, Example 2-171-2 | US9957235, 2-171 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390528(US10442772, Example 2-175-2 | US9957235, 2-172 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390647(US10442772, Example 2-237-1 | US9957235, 2-237 | U...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM415929(US10442772, Example 2-237-2)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
LigandPNGBDBM50394902(CHEMBL2165493)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V125XNPubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390660(US10442772, Example 2-246-2 | US9957235, 2-246-1 |...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM415926(US10442772, Example 2-236-2)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390460(US10442772, Example 2-123-2 | US9957235, 2-123 | U...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
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