Compile Data Set for Download or QSAR
Found 57 with Last Name = 'argentieri' and Initial = 'r'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198005(10,16-bis(hydroxymethyl)-22-[(1E)-3-(1H-imidazol-1...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295819(12,13-(2,3-cis-dihydroxy-butan-1,4-yl)-12,13-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198018(10,16-bis(hydroxymethyl)-4,14,18-triazaheptacyclo[...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295821(12,13-(2-hydroxy-butan-1,4-yl)-12,13-dihydro-5,7-d...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75DP0PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295820(12,13-(2-hydroxy-pentan-1,5-yl)-12,13-dihydro-5,7-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295818(12,13-(2,3-cis-dihydroxy-pentan-1,5-yl)-12,13-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295817(12,13-[2-carboxy-cis-2,3-dihydroxy-1,4-butyl]-6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198014(16-(hydroxymethyl)-22-[(1E)-3-(1H-imidazol-1-yl)pr...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295812(12,13-(3,4-Cis-dihyroxy-1,6-hexyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198020(16,16-bis(hydroxymethyl)-4,14,18-triazaheptacyclo[...)copy SMILEScopy InChI
Affinity DataIC50: 13.5nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198025(10,16,22-tris(hydroxymethyl)-4,14,18-triazaheptacy...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295816((16S,17R)-16-{[3-(dimethylamino)pyrrolidin-1-yl]ca...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198023(22-bromo-16-(hydroxymethyl)-3-oxo-4,14,18-triazahe...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198004(16-(hydroxymethyl)-4,14,18-triazaheptacyclo[12.10....)copy SMILEScopy InChI
Affinity DataIC50: 17.5nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198006(22-bromo-16-(hydroxymethyl)-4,14,18-triazaheptacyc...)copy SMILEScopy InChI
Affinity DataIC50: 23.5nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198009(16-hydroxy-16-(hydroxymethyl)-4,14,18-triazaheptac...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198019(22-[(1E)-3-(4,5-dihydro-1H-imidazol-2-ylamino)prop...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198017(16-(1,3-dihydroxypropan-2-ylidene)-4,14,18-triazah...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295813(12,13-(1,6-hex-cis-3-enyl)-6,7,12,13-tetrahydro-5-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295814(12,13-(1,4-but-cis-2-enyl)-6,7,12,13-tetrahydro-5-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM2581(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198015(22-bromo-16-(hydroxymethyl)-10-[(propan-2-yloxy)me...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198010(16-methylidene-4,14,18-triazaheptacyclo[12.10.2.0^...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198022(16-(hydroxymethyl)-10-[(propan-2-yloxy)methyl]-4,1...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM26199(N-[4-(4-methylpiperazin-1-yl)phenyl]-3-phenyl-1H-p...)copy SMILEScopy InChI
Affinity DataIC50: 98nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75DP0PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198024(16-(hydroxymethyl)-22-[(E)-2-(1H-imidazol-1-yl)eth...)copy SMILEScopy InChI
Affinity DataIC50: 109nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198012(16-hydroxy-4,14,18-triazaheptacyclo[12.10.2.0^{2,6...)copy SMILEScopy InChI
Affinity DataIC50: 142nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295815(12,13-diallyl-6,7,12,13-tetrahydro-5-oxo-5H-indolo...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198016((2E)-N-[3-(dimethylamino)propyl]-3-[16-(hydroxymet...)copy SMILEScopy InChI
Affinity DataIC50: 237nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198008(10-[(dimethylamino)methyl]-16-(hydroxymethyl)-4,14...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198021(16-(hydroxymethyl)-22-[(E)-2-(pyridin-2-yl)ethenyl...)copy SMILEScopy InChI
Affinity DataIC50: 354nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198002(16-(hydroxymethyl)-22-[(E)-2-(4-methyl-1,3-thiazol...)copy SMILEScopy InChI
Affinity DataIC50: 592nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50198003((2E)-3-[16-(hydroxymethyl)-5-oxo-4,14,18-triazahep...)copy SMILEScopy InChI
Affinity DataIC50: 686nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KTPPubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 689nMAssay Description:Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM16018(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)copy SMILEScopy InChI
Affinity DataIC50: 957nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75DP0PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GQ8PubMed
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