Compile Data Set for Download or QSAR
Found 40 with Last Name = 'boulter' and Initial = 'r'
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:A FlashPlate scintillation proximity assay has been used to identify inhibitors of PARP-2. PARP-2 protein (recombinant) was bound down by a PARP-2 sp...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27567(4-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27546(4-[(3-{[4-(pyrimidin-2-yl)piperazin-1-yl]carbonyl}...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27570(4-[(4-fluoro-3-{[4-(oxolan-3-ylcarbonyl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27545(4-[(4-fluoro-3-{[4-(pyridin-2-yl)piperazin-1-yl]ca...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27547(4-[(4-fluoro-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27569(4-[(4-fluoro-3-{[4-(oxolan-2-ylcarbonyl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27563(4-[(3-{[4-(cyclopropylmethyl)piperazin-1-yl]carbon...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27543(4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27562(4-({3-[(4-butylpiperazin-1-yl)carbonyl]-4-fluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27565(4-({4-fluoro-3-[(4-propanoylpiperazin-1-yl)carbony...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27553(4-({4-fluoro-3-[(4-phenylpiperazin-1-yl)carbonyl]p...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27551(4-[(4-fluoro-3-{[4-(morpholin-4-ylcarbonyl)piperaz...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27555(4-({3-[(4-benzoylpiperazin-1-yl)carbonyl]-4-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27560(4-({3-[(4-ethylpiperazin-1-yl)carbonyl]-4-fluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27564(4-({3-[(4-acetylpiperazin-1-yl)carbonyl]-4-fluorop...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27561(4-({4-fluoro-3-[(4-propylpiperazin-1-yl)carbonyl]p...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27535(4-[(4-fluoro-3-{[4-(2-hydroxyethyl)-1,4-diazepan-1...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27550(4-[(3-{[4-(morpholin-4-ylcarbonyl)piperazin-1-yl]c...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27549(4-[(3-{[4-(ethanesulfonyl)piperazin-1-yl]carbonyl}...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27539(4-[(4-fluoro-3-{[4-(morpholin-4-ylcarbonyl)-1,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27544(4-[(3-{[4-(pyridin-2-yl)piperazin-1-yl]carbonyl}ph...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27554(4-({3-[(4-benzoylpiperazin-1-yl)carbonyl]phenyl}me...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27557(4-[(4-fluoro-3-{[4-(2-hydroxyethyl)piperazin-1-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27540(4-({3-[(4-acetyl-1,4-diazepan-1-yl)carbonyl]-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27548(4-[(3-{[4-(ethanesulfonyl)piperazin-1-yl]carbonyl}...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27541(4-({3-[(4-cyclopropanecarbonyl-1,4-diazepan-1-yl)c...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27559(4-({4-fluoro-3-[(4-methylpiperazin-1-yl)carbonyl]p...)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27568(4-({3-[(4-cyclohexanecarbonylpiperazin-1-yl)carbon...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27536(4-({3-[(4-benzyl-1,4-diazepan-1-yl)carbonyl]phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27534(4-[(3-{[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]carbo...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27538(4-[(3-{[4-(morpholin-4-ylcarbonyl)-1,4-diazepan-1-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27537(4-[(3-{[4-(ethanesulfonyl)-1,4-diazepan-1-yl]carbo...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27556(4-[(3-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}...)copy SMILEScopy InChI
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27552(4-({3-[(4-phenylpiperazin-1-yl)carbonyl]phenyl}met...)copy SMILEScopy InChI
Affinity DataIC50: 51nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27558(4-({3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}met...)copy SMILEScopy InChI
Affinity DataIC50: 88nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:An AlphaScreen (Perkin-Elmer) assay was developed in which His-tagged recombinant TANK-1 protein was incubated with biotinylated NAD+ in a 384-well P...More data for this Ligand-Target Pair