Found 189 with Last Name = 'castelli' and Initial = 'r' 
Affinity DataKi: 300nMAssay Description:Competitive inhibition of biotinylated ephrin-A1-Fc binding to EphA2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Competitive inhibition of biotinylated ephrin-A1-Fc binding to EphA2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 800nMAssay Description:Competitive inhibition of biotinylated ephrin-A1-Fc binding to EphA2 (unknown origin)More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 2.45E+3nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 7.76E+3nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 8.42E+3nMAssay Description:Apparent affinity to inhibit binding of [3H]-pCCK-8 to Cholecystokinin type A receptor of guinea pig pancreatic membranesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 9.70E+3nMAssay Description:Affinity of compound to Sigma opioid receptor labelled with [3H](+)-3-PPPMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 1.15E+4nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 1.34E+4nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataKi: 2.11E+4nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2SQ946RPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2SQ946RPubMedDrugBank
MMDB
PDB
3D Structure (crystal)Affinity DataIC50: 0.320nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2SQ946RPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2SQ946RPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2H41VT4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2H41VT4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.620nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 0.620nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-17(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Apparent affinity to inhibit binding of [3H]-pCCK-8 to Cholecystokinin type A receptor of guinea pig pancreatic membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-17(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University of Alfenas
Curated by ChEMBL
Federal University of Alfenas
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by...More data for this Ligand-Target Pair
