Compile Data Set for Download or QSAR
Found 126 with Last Name = 'cozens' and Initial = 'r'
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM201((2S)-N-[(2S,3S)-4-[(2S)-N'-(cyclohexylmethyl)-2-ac...)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066461(CHEMBL326408 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066474(((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-me...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066462(CHEMBL326347 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066473(CHEMBL325900 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066476(CHEMBL333386 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066459(((S)-1-{(1S,2S)-1-Benzyl-3-[N'-((S)-2-ethoxycarbon...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM213(2-Methyl-4-[[N-(methoxycarbonyl)-L-valinyl]amino]-...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM206(1-Cyclohexyl-2-N-[[(methoxycarbonyl)-L-valinyl]ami...)copy SMILEScopy InChI
Affinity DataIC50: 27nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066475(((S)-1-{N'-[(2S,3S)-2-Hydroxy-3-((S)-2-methoxycarb...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066472(((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-me...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066468(CHEMBL324521 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4876(1-(3,4-Dichloroanilino)-4-(4-pyridylmethyl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM214(1-(4-Methoxyphenyl)-2-[[N-(methoxycarbonyl)-L-vali...)copy SMILEScopy InChI
Affinity DataIC50: 31nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066463(((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-me...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066465(CHEMBL442013 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066467(CHEMBL114039 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066469(CHEMBL113943 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066471(((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM216(2-Methyl-4-[[N-(benzyloxycarbonyl)-L-valinyl]amino...)copy SMILEScopy InChI
Affinity DataIC50: 37nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4851((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4871(1-(3-Methylanilino)-4-(4-pyridylmethyl)phthalazine...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4878(1-(3,5-Dimethylanilino)-4-(4-pyridylmethyl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066477(((S)-1-{N'-(4-Diethylamino-benzyl)-N'-[(2S,3S)-2-h...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066464(CHEMBL116165 | {(S)-1-[N'-[(2S,3S)-2-Hydroxy-3-((S...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM215(1-Cyclohexyl-2-[[N-(benzyloxycarbonyl)-L-valinyl]a...)copy SMILEScopy InChI
Affinity DataIC50: 41nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM217(1-(4-Methoxyphenyl)-2-[[N-(benzyloxycarbonyl)-L-va...)copy SMILEScopy InChI
Affinity DataIC50: 49nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066460(((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM207(1-Cyclohexyl-2-[[N-(ethoxycarbonyl)-L-valinyl]amin...)copy SMILEScopy InChI
Affinity DataIC50: 56nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066466(((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4870(1-Anilino-4-(4-pyridylmethyl)phthalazine Dihydroch...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4853(1-(4-Chlorophenoxy)-4-(4-pyridylmethyl)phthalazine...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM211(2-methoxyethyl N-[(1S)-1-{[(2S,3S)-4-[(2S)-N'-(cyc...)copy SMILEScopy InChI
Affinity DataIC50: 62nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM208(CGP 53820 analog | methyl N-[(1S)-1-{[(2S,3S)-4-[(...)copy SMILEScopy InChI
Affinity DataIC50: 67nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM205(2-(2-methoxyethoxy)ethyl N-[(1S)-1-{[(2S,3S)-4-[(2...)copy SMILEScopy InChI
Affinity DataIC50: 67nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4876(1-(3,4-Dichloroanilino)-4-(4-pyridylmethyl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4854(1-(4-Chlorophenylsulfanyl)-4-(4-pyridylmethyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 70nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066470(((S)-1-{N'-[4-(2-tert-Butyl-2H-tetrazol-5-yl)-benz...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM209(CGP 53820 analog | ethyl N-[(1S)-1-{[(2S,3S)-4-[(2...)copy SMILEScopy InChI
Affinity DataIC50: 76nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4851((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 77nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4875(1-(3-Hydroxyanilino)-4-(4-pyridylmethyl)phthalazin...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4871(1-(3-Methylanilino)-4-(4-pyridylmethyl)phthalazine...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50066458(((S)-1-{(1S,2S)-1-Benzyl-3-[N-biphenyl-4-ylmethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H1315DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM218(1-Cyclohexyl-2-[[N-(ethoxycarbonyl)-L-valinyl]amin...)copy SMILEScopy InChI
Affinity DataIC50: 126nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4867(CGP79787 Analog 50 | CHEMBL75077 | N-(4-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM212(2-methoxyethyl N-[(1S)-1-{[(2S,3S)-4-[(2S)-N'-(cyc...)copy SMILEScopy InChI
Affinity DataIC50: 134nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4877(1-(3-Methoxy-4-chloroanilino)-4-(4-pyridylmethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M92R5PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Ciba-Geigy Ltd.

LigandPNGBDBM210(CGP 53820 analog | ethyl N-[(1S)-1-{[(2S,3S)-4-[(2...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 6.0 T: 2°CAssay Description:A peptide cleavage assay was performed using the icosapeptide H-Arg-Arg-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Asn-Ile-Gln-Gly-Arg-Arg-OH, a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8J7QPubMed
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