Compile Data Set for Download or QSAR
Found 88 with Last Name = 'sakowicz' and Initial = 'r'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.230nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.350nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220195(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220159(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220201(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220155(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220176(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220162(CHEMBL243883 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220188(CHEMBL244126 | N-(4'-t-butyl-4-biphenylyl)urea)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220192(CHEMBL397249 | N-(4'-isopropyl-4-biphenylyl)urea)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220177(CHEMBL389588 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220172(4'-(trifluoromethyl)-4-biphenylyl sulfamate | CHEM...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220209(CHEMBL242780 | N-[3-(methoxy)-4'-(trifluoromethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220170(CHEMBL243649 | N-[3-Chloro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220181(CHEMBL397673 | N-[4-(2,2,3,3-tetrafluoro-2,3-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 87.3nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220174(1-[4'-(trifluoromethyl)-4-biphenylyl]methanesulfon...)copy SMILEScopy InChI
Affinity DataIC50: 118nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220197(CHEMBL242357 | N-[3-methyl-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 141nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 161nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 162nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220157(CHEMBL395487 | N-[3'-amino-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 167nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220179(CHEMBL243906 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)copy SMILEScopy InChI
Affinity DataIC50: 176nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220189(CHEMBL243681 | N-[3-cyano-4'-(trifluoromethyl)-4-b...)copy SMILEScopy InChI
Affinity DataIC50: 196nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220203(CHEMBL244511 | N-{4'-[(trifluoromethyl)thio]-4-bip...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220178(CHEMBL244510 | N-(4'-bromo-3,3'-difluoro-4-bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 262nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
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