Compile Data Set for Download or QSAR
Found 178 with Last Name = 'swanson' and Initial = 'r'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418183(CHEMBL1761688)copy SMILEScopy InChI
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of labeled-dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336144((1R,3S)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418959(CHEMBL1807875)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418961(CHEMBL1807877)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17922(2-(1-{[(2S,4R)-4-(benzyloxy)-1-[2-(3-methoxy-4-{[(...)copy SMILEScopy InChI
Affinity DataIC50: 0.940nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17930(2-(4-{[(2S,3S)-3-hydroxy-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 0.960nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17937(2-(4-{[(2S)-1-[2-(3-methoxy-4-{[(2-methylphenyl)ca...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17931(2-(4-{[(2S,4S)-4-fluoro-1-[2-(3-methoxy-4-{[(2-met...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17924(2-(1-{[(2S,4R)-4-hydroxy-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17920(2-(1-{[(2S,4R)-4-methoxy-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17934(2-(4-{[(2S,4S)-4-chloro-1-[2-(3-methoxy-4-{[(2-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17927(2-(4-{[(2S,4S)-1-[2-(3-methoxy-4-{[(2-methylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17929(2-(4-{[(2S,3S)-3-(benzyloxy)-1-[2-(3-methoxy-4-{[(...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17928(2-(4-{[(2S,4S)-1-[2-(3-methoxy-4-{[(2-methylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17933(2-(4-{[(2S)-4,4-difluoro-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157050(CHEMBL361914 | [4-(1-{2-[3-Methoxy-4-(3-o-tolyl-ur...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17926(2-(4-{[(2S,3R,4S)-3,4-dihydroxy-1-[2-(3-methoxy-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17935(2-[4-({2-[2-(3-methoxy-4-{[(2-methylphenyl)carbamo...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17925(2-(4-{[(3aR,4S,6aS)-5-[2-(3-methoxy-4-{[(2-methylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157039(CHEMBL179780 | [4-(1-{2-[3-Methoxy-4-(3-o-tolyl-ur...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17921(2-(4-{[(2S,4R)-4-(benzyloxy)-1-[2-(3-methoxy-4-{[(...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157041(CHEMBL185571 | [4-(1-{2-[3-Methoxy-4-(3-o-tolyl-ur...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17918(2-(4-{[(2S)-1-[2-(3-methoxy-4-{[(2-methylphenyl)ca...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human deoxycytidine kinase by lysate filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4HVKPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418981(CHEMBL1807878)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17919(2-(4-{[(2S,4R)-4-methoxy-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17932(2-(4-{[(2S,4R)-4-fluoro-1-[2-(3-methoxy-4-{[(2-met...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17936(2-(4-{[(2S)-1-[2-(3-methoxy-4-{[(2-methylphenyl)ca...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157044(CHEMBL369731 | [1-(1-{2-[4-(3-o-Tolyl-ureido)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336144((1R,3S)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K074JCPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50325890(CHEMBL1224536 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN0958PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418965(CHEMBL1807883)copy SMILEScopy InChI
Affinity DataIC50: 3.16nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157046(4-[(1-{2-[4-(3-o-Tolyl-ureido)-phenyl]-acetyl}-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418964(CHEMBL1807882)copy SMILEScopy InChI
Affinity DataIC50: 3.98nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17917(2-(1-{[(3S)-4-[2-(4-{[(2-methylphenyl)carbamoyl]am...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157048(CHEMBL360163 | [1-(4-{2-[4-(3-o-Tolyl-ureido)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157034(5-(3-Methyl-butylcarbamoyl)-5-[(1-{2-[4-(3-o-tolyl...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50325894(CHEMBL1224615 | N-(3-((6-(benzo[d][1,3]dioxol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN0958PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418960(CHEMBL1807876)copy SMILEScopy InChI
Affinity DataIC50: 5.01nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Daiichi Pharmaceutical

LigandPNGBDBM17923(2-(4-{[(2S,4R)-4-hydroxy-1-[2-(3-methoxy-4-{[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMpH: 7.5 T: 2°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1J5HPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50325892(CHEMBL1224613 | N-(3-((6-(benzo[d][1,3]dioxol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN0958PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50325888(CHEMBL1224534 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN0958PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157035(5-[(1-{2-[4-(3-o-Tolyl-ureido)-phenyl]-acetyl}-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336143((1S,3R)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K074JCPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157040(5-[(3-{2-[4-(3-o-Tolyl-ureido)-phenyl]-acetyl}-thi...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418979(CHEMBL1807879)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50418963(CHEMBL1807881)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32X1MPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157051(CHEMBL181708 | [4-(1-{2-[4-(3-o-Tolyl-ureido)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Daiichi Pharmaceutical Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50157053(CHEMBL180106 | [4-(1-{2-[4-(3-o-Tolyl-ureido)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of VLA-4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3F7QPubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336162(4-chloro-N-cyclopentyl-5-(4-(trifluoromethyl)pheny...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K074JCPubMed
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