Compile Data Set for Download or QSAR
Found 31 with Last Name = 'troschuetz' and Initial = 'r'
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31123(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11b)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31127(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11f)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22332(2-amino-5-hydroxyindole, 3n | ethyl 2-[(3-chloroph...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31125(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11d)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31122(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11a)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31129(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11h)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31140(1H-benzo[g]indole-3-carboxylate, 19)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31122(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11a)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cells assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22324(2-amino-5-hydroxyindole, 3j | ethyl 5-hydroxy-2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22322(2-piperazinyl-5-hydroxyindole, 3h | ethyl 2-[4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50304663(CHEMBL595040 | ethyl 2-(3-chlorobenzyl)-5-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22326(2-amino-5-hydroxyindole, 3l | ethyl 5-hydroxy-2-[(...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50304664(CHEMBL605093 | ethyl 1-(biphenyl-4-yl)-2-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22318(2-piperazinyl-5-hydroxyindole, 3f | ethyl 5-hydrox...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31124(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11c)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22325(2-amino-5-hydroxyindole, 3k | ethyl 5-hydroxy-2-[(...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22331(2-amino-5-hydroxyindole, 3m | ethyl 2-[bis(prop-2-...)copy SMILEScopy InChI
Affinity DataIC50: 7.10E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cells assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31132(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11k)copy SMILEScopy InChI
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22329(2-aminoindole, 9b | ethyl 2-[(1-phenylethyl)amino]...)copy SMILEScopy InChI
Affinity DataIC50: 9.80E+3nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22330(2-amino-5-hydroxyindole, 11 | 5-hydroxy-2-[(1-phen...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31123(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11b)copy SMILEScopy InChI
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cells assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22320(2-piperazinyl-5-methoxyindole, 7f | ethyl 5-methox...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22321(2-piperazinyl-5-hydroxyindole, 3g | ethyl 2-[4-(4-...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22323(2-piperazinyl-5-hydroxyindole, 3i | ethyl 2-(4-ben...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22328(2-amino-5-hydroxyindole, 14 | methyl 5-hydroxy-2-[...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22333(2-amino-5-hydroxyindole, 3o | ethyl 5-hydroxy-2-(p...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22327(2-aminoindole, 9a | methyl 2-[(1-phenylethyl)amino...)copy SMILEScopy InChI
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC30PQPubMed