Compile Data Set for Download or QSAR
Found 183 with Last Name = 'earl' and Initial = 'ra'
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50041291(2-[(R)-3-(1,1-Dimethyl-2-phenyl-ethyl)-2,4,8-triox...)copy SMILEScopy InChI
Affinity DataKi:  0.930nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037348(1N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-(3-...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036127(CHEMBL11391 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-...)copy SMILEScopy InChI
Affinity DataKi:  4.5nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037341(4-{2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036112(CHEMBL11403 | {6-Oxo-2-phenyl-1-[(3,3,3-trifluoro-...)copy SMILEScopy InChI
Affinity DataKi:  6.60nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037375(CHEMBL275043 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036103(CHEMBL11098 | {2-(4-Fluoro-phenyl)-6-oxo-1-[(3,3,3...)copy SMILEScopy InChI
Affinity DataKi:  8.20nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036078(1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-1-isopropyl-2-o...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037342(1N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-(3-...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036122(CHEMBL11336 | {2-(4-Fluoro-phenyl)-6-oxo-1-[(3,3,3...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetChymotrypsin-C(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036127(CHEMBL11391 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-...)copy SMILEScopy InChI
Affinity DataKi:  55nMAssay Description:The compound was evaluated for the binding affinity against bovine pancreatic chymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036093(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)copy SMILEScopy InChI
Affinity DataKi:  101nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50453643(CHEMBL2371666)copy SMILEScopy InChI
Affinity DataKi:  210nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
ZENECA Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037115(2-(3-Acetylamino-2-oxo-2H-pyridin-1-yl)-N-(3,3,3-t...)copy SMILEScopy InChI
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of Human Leukocyte Elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251H7PPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMedDrugBank
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127999(1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3-yl]-piperi...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001778((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002002(1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMedDrugBank
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053194(CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMedDrugBank
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127982(1-(2-{4-[1-(4-Fluoro-phenyl)-2,3-dihydro-1H-indol-...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128003(CHEMBL52627 | MK-499 | N-[1'-(6-cyano-1,2,3,4-tetr...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127983(4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethy...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM50136106(4-(6-Benzyl-benzo[1,3]dioxol-5-yl)-benzenesulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX78WKPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Compound was tested for the inhibition of recombinant human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMedMMDB
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM50136109(5-Cyclohexylidenemethyl-6-(4-methanesulfonyl-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Compound was tested for the inhibition of recombinant human Prostaglandin G/H synthase 2 (COX-2) by enzyme AssayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX78WKPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMedMMDB
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127989(1-{2-[4-(5-Chloro-1-phenyl-1H-indol-3-yl)-piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128000(CHEMBL415944 | [4-(5-Chloro-3-{1-[2-(2-oxo-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128001(1-{2-[4-(5-Chloro-1-cyclohexyl-1H-indol-3-yl)-pipe...)copy SMILEScopy InChI
Affinity DataIC50: 137nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMedDrugBank
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM50136108(5-Cycloheptylidenemethyl-6-(4-methanesulfonyl-phen...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX78WKPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:AP-1 suppression activity using freshly prepared DMSO stockMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002009(5-Chloro-1-(4-fluoro-phenyl)-3-piperidin-4-yl-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 204nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3FX0PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM50168167(CHEMBL364966 | [3-(4-Methanesulfonyl-phenyl)-5-tri...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9VSZPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 2 in human bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072163(2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072154(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:AP-1 suppression activity using one week old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:AP-1 suppression activity using one month old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072166(2,3-Bis-[1-amino-1-(4-hydroxy-phenylsulfanyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
NitroMed, Inc

Curated by ChEMBL
LigandPNGBDBM50144866(1-Cyclohexyl-5-(4-methanesulfonyl-phenyl)-3-nitroo...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 2 in human bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55MZFPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50072154(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2HNNPubMed
Displayed 1 to 50 (of 183 total ) | Next | Last >>
Jump to: