TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataKi: 50nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Affinity DataIC50: 2.26nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMT: 2°CAssay Description:Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMT: 2°CAssay Description:Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 5.18nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 13.3nMT: 2°CAssay Description:Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
Affinity DataIC50: 23.3nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at RORC2 in BALB/c mouse Th17 cells assessed as inhibition of IL17A production after 4 days by electrochemiluminescence assa...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 51.3nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 55.5nMpH: 7.5 T: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Karo Bio AB (now Karo Pharma AB)
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair