Found 62 with Last Name = 'doerksen' and Initial = 'rj' TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Displacement of [3H]CGP54626 from GABA-B receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataKi: 9.20E+4nMAssay Description:Displacement of [3H]CGP54626 from GABA-B receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataKi: 1.77E+5nMAssay Description:Displacement of [3H]CGP54626 from GABA-B receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.42E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of recombinant equine serum BuChE using butyryl thiocholine iodide as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.89E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.68E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.74E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.23E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.31E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.91E+3nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The University of Mississippi
Curated by ChEMBL
The University of Mississippi
Curated by ChEMBL
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of recombinant equine serum BuChE using butyryl thiocholine iodide as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of recombinant equine serum BuChE using butyryl thiocholine iodide as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of recombinant equine serum BuChE using butyryl thiocholine iodide as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of recombinant equine serum BuChE using butyryl thiocholine iodide as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.34E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibition of recombinant human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Homo sapiens (Human))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Homo sapiens (Human))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataEC50: 5.37E+3nMAssay Description:Positive allosteric modulator activity at GABA-B receptor (unknown origin) assessed as potentiation of 1 uM GABA-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Homo sapiens (Human))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Homo sapiens (Human))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: 4.00E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataKd: 1nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataEC50: 8.60nMAssay Description:Agonist activity at human recombinant GABA-B receptorMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Homo sapiens (Human))
University of Mississippi
Curated by ChEMBL
University of Mississippi
Curated by ChEMBL
Affinity DataEC50: 5.74E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
