Compile Data Set for Download or QSAR
Found 634 with Last Name = 'schultz' and Initial = 'rm'
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288820((S)-2-{(S)-4-[4-(2,4-Diamino-pyrimidin-5-yl)-butyl...)copy SMILEScopy InChI
Affinity DataKi:  0.00500nMAssay Description:Binding affinity of the compound against Recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6XQ2
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288821((S)-2-{(S)-4-[3-(2,4-Diamino-pyrimidin-5-yl)-propy...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMAssay Description:Binding affinity of the compound against Recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6XQ2
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)copy SMILEScopy InChI
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073752((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi:  0.690nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi:  9.90nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi:  710nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetThymidylate synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetThymidylate synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50288821((S)-2-{(S)-4-[3-(2,4-Diamino-pyrimidin-5-yl)-propy...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity of the compound against Recombinant human thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6XQ2
TargetThymidylate synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073752((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetThymidylate synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetThymidylate synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50288820((S)-2-{(S)-4-[4-(2,4-Diamino-pyrimidin-5-yl)-butyl...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity of the compound against Recombinant human thymidylate synthase (TS).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6XQ2
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073752((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)copy SMILEScopy InChI
Affinity DataKi:  9.20E+3nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)copy SMILEScopy InChI
Affinity DataKi:  5.60E+4nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SX6CCTPubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbINGMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BTCPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6745(1,7-Annulated indolocarbazole deriv. 13Ab | 7-fluo...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W3HPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6811(18,23-dimethyl-3,13,18-triazahexacyclo[14.7.0.0^{2...)copy SMILEScopy InChI
Affinity DataIC50: 2nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164242(6-(5-Phenyl-2-piperidin-4-yl-3H-imidazol-4-yl)-1-(...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6832(3-[3-(4-hydroxypiperidin-1-yl)propyl]-6-methoxy-18...)copy SMILEScopy InChI
Affinity DataIC50: 4nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164228(1-(isopropylsulfonyl)-6-(4-phenyl-1H-imidazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164240(6-[5-(4-Fluoro-phenyl)-3H-imidazol-4-yl]-1-(propan...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164236(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164230(6-[5-(4-Fluoro-phenyl)-2-isopropyl-3H-imidazol-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164239(6-[2-Ethyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164229(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164232(6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6838(1-(2-{18-methyl-12,14-dioxo-3,13,18-triazahexacycl...)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6846(5-{2-[(4-hydroxycyclohexyl)amino]ethyl}-18-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164231(6-[2-(1-Isobutyl-piperidin-4-yl)-5-phenyl-3H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6803(6-methoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6815(6-fluoro-18,23-dimethyl-3,13,18-triazahexacyclo[14...)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6800(6-hydroxy-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164232(6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6816(6-methoxy-18,23-dimethyl-3,13,18-triazahexacyclo[1...)copy SMILEScopy InChI
Affinity DataIC50: 7nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6818(3-(3-hydroxypropyl)-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 8nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6840(5-[2-(4-hydroxypiperidin-1-yl)ethyl]-18-methyl-3,1...)copy SMILEScopy InChI
Affinity DataIC50: 8nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6756(1,7-Annulated indolocarbazole deriv. 16-b | 7-fluo...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W3HPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6796(18-methyl-6-(trifluoromethyl)-3,13,18-triazahexacy...)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6801(6-hydroxy-18-methyl-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6794(6-fluoro-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6804(6-ethoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6843(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6797(18-methyl-12,14-dioxo-3,13,18-triazahexacyclo[14.7...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6747(1,7-Annulated indolocarbazole deriv. 13Bc | 7-brom...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W3HPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6842(18-methyl-5-[2-(piperidin-1-yl)ethyl]-3,13,18-tria...)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6794(6-fluoro-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6797(18-methyl-12,14-dioxo-3,13,18-triazahexacyclo[14.7...)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbINGMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BTCPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Lilly Spain S.A.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of Cyclin E-cyclin-dependent kinase 2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BTCPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6818(3-(3-hydroxypropyl)-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 12nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
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