Compile Data Set for Download or QSAR
Found 341 with Last Name = 'singhaus' and Initial = 'rr'
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)copy SMILEScopy InChI
Affinity DataIC50: 0.0630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)copy SMILEScopy InChI
Affinity DataIC50: 0.0790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233244(CHEMBL4068954)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233248(CHEMBL4096224)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis at 21 hrs post-st...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233228(CHEMBL4060644)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233255(CHEMBL4069318)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233226(CHEMBL4089558)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-MIP-1beta production at 21 hrs post-s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233230(CHEMBL4099004)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233249(CHEMBL4081685)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233229(CHEMBL4088857)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159508(CHEMBL3786078)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378590(CHEMBL611735)copy SMILEScopy InChI
Affinity DataIC50: 0.810nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W3SPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 0.920nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W3SPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233252(CHEMBL4080978)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233250(CHEMBL4099698)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305072(8-chloro-3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305073(3-benzyl-8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305064(3-(3-(3-(3-methyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis by measuring cell...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305070(4-(3-(3-(ethylsulfonyl)phenoxy)phenyl)-3-methyl-8-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305068(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35107(biarylether amide quinoline, 4g)copy SMILEScopy InChI
Affinity DataIC50: 1.90nM EC50:  138nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VGVPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305060(4-(3-(3-fluoro-5-(methylsulfonyl)phenoxy)phenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human whole blood assessed as reduction in TNFalpha/QCD-OPh/zVAD FMK/SMAC mimetic RMT 5265-MIP-1beta production after 6 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233241(CHEMBL4071080)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378593(CHEMBL612007)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W3SPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  93nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  71nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35094(biarylether alcohol quinoline, 5f)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  233nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5M54PubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305067(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-8-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W3SPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35099(biarylether alcohol quinoline, 5i)copy SMILEScopy InChI
Affinity DataIC50: 2.5nM EC50:  108nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5M54PubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305069(3-methyl-4-(3-(3-(propylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35105(biarylether amide quinoline, 4e)copy SMILEScopy InChI
Affinity DataIC50: 2.60nM EC50:  98nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VGVPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35104(biarylether amide quinoline, 4d)copy SMILEScopy InChI
Affinity DataIC50: 2.80nM EC50:  144nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VGVPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305074(4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluo...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
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