Compile Data Set for Download or QSAR
Found 126 with Last Name = 'barbosa' and Initial = 's'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5924(BMS-387032 analog 14 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5668(2-amino-5-thio-substituted thiazole 45 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5660(2-amino-5-thio-substituted thiazole 25 | 2-aminoth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5930(BMS-387032 analog 20 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176588(3-acetamido-N-(3-cyano-5-methyl-4-(4-phenoxyphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184822(CHEMBL383671 | methyl 4-(4-fluoro-2-methyl-1H-indo...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184818(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176580(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5934(BMS-387032 analog 24 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184817(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184812(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5923(3-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5936(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176595(CHEMBL377288 | ethyl 3-cyano-4-(4-(2-methoxyphenox...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176569(CHEMBL201389 | methyl 3-cyano-5-methyl-4-(4-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184811((R)-1-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184816(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyr...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176559(1-(3-cyano-4-(4-(2-methoxyphenoxy)phenylamino)-5-m...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5683(2-amino-5-thio-substituted thiazole 31 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176593(1-(3-cyano-4-(4-(3-methoxyphenoxy)phenylamino)-5-m...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176592(1-(3-cyano-4-(4-(2-fluorophenoxy)phenylamino)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176572(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184808((S)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176586(CHEMBL202063 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5932(1-Methyl-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]...)copy SMILEScopy InChI
Affinity DataIC50: 43nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176567(2-morpholinoethyl 3-cyano-4-(4-(2-methoxyphenoxy)p...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5926(BMS-387032 analog 16 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5928((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176564(2-morpholinoethyl 3-cyano-5-methyl-4-(4-phenoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50371875(CHEMBL270996)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9JTXPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184821(CHEMBL206545 | N-(3-(4-(4-fluoro-2-methyl-1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176565(CHEMBL202385 | ethyl 4-(4-benzylphenylamino)-3-cya...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5933(BMS-387032 analog 23 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 74nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176576(2-morpholinoethyl 3-cyano-4-(4-(3-methoxyphenoxy)p...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184820(CHEMBL205283 | methyl 5-methyl-4-(2-methyl-1H-indo...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5929((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176571(CHEMBL201819 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184814(CHEMBL207842 | ethyl 4-(1H-indol-5-yloxy)-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176603(CHEMBL380765 | ethyl 3-cyano-5-methyl-4-(4-phenoxy...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50371877(CHEMBL408443)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inhibition of human CYP3A4 using 7-benzyl-trifluoromethyl coumarinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9JTXPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176575(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 147nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GHTPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
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