TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 5nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 22nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 26nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 43nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 74nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human CYP3A4 using 7-benzyl-trifluoromethyl coumarinMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 147nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair