TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Sinhgad College of Pharmacy
Curated by ChEMBL
Sinhgad College of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sinhgad College of Pharmacy
Curated by ChEMBL
Sinhgad College of Pharmacy
Curated by ChEMBL
Affinity DataKi: 1.92nMAssay Description:Binding affinity to 5HT2A (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Sinhgad College of Pharmacy
Curated by ChEMBL
Sinhgad College of Pharmacy
Curated by ChEMBL
Affinity DataKi: 47nMAssay Description:Binding affinity to adrenergic alpha1B receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Sinhgad College of Pharmacy
Curated by ChEMBL
Sinhgad College of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2.88E+3nMAssay Description:Binding affinity to 5HT1B (unknown origin)More data for this Ligand-Target Pair
TargetFalcipain 2(Plasmodium falciparum)
International Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
International Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
Affinity DataKi: 3.80E+3nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 5.30E+3nMAssay Description:Competitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent peptide substrate in presence of NAD+ by Lineweaver-Burk p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 9.80E+3nMAssay Description:Noncompetitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by Lineweaver-Burk plot a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of full-length human N-terminal GST-tagged SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity u...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 297nMAssay Description:Inhibition of full-length human N-terminal GST-tagged SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity u...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 747 residues) expressed in Escherichia coli BL21 (DE3) using AMC-labeled p53-derived acetylated lysine ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human FLAG-tagged SIRT1 expressed in HEK293 cells using [3H]-H3 peptide as substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant human SIRT1 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor de Lys ass...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human N-terminal 6His-tagged SIRT2 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of recombinant human SIRT2 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by fluorescence analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SIRT2 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human SIRT2 using biotin labeled histone H4 peptide with an acetylated lysine 4 as substrate measured after 1 hr by luminescence analys...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity preincubated with protein followed by addition of AMC-tagged Arg-His-Lys-Lys(Ac) (379 to...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of SIRT1 (unknown origin) using acetylated lysine as substrate by Fluor de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged SIRT2 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity preincubated with protein followed by addition of AMC-tagged Arg-His-Lys-Lys(Ac) (379 to...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human SIRT1 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by fluorescence analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of human GST-tagged SIRT1 (18 to 340 residues) expressed in Escherichia coli BL21 (DE3)LysS using acetylated HeLa histones as substrate me...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human SIRT1 assessed as NAD+-dependent deacetylase activity using acetylated tubuline as substrate measured after overnight incubation ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Non-competitive inhibition of recombinant human SIRT1 using acetylated histone as substrate measured after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of recombinant human SIRT1 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor de Lys ass...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human SIRT1 expressed in bacterial expression system assessed as reduction in conversion of [3H]acetyl-H4 to [3H]acetic acid measured a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of human GST-tagged SIRT2 expressed in bacterial expression system assessed as deacetylation activity using [3H]acetyl-H4 peptide as subst...More data for this Ligand-Target Pair