Compile Data Set for Download or QSAR
Found 64 with Last Name = 'chauhan' and Initial = 's'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50029257((3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)p...)copy SMILEScopy InChI
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1JPXPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50270453((R)-4-(3-(2-amino-4-(4-fluorophenyl)thiazol-5-yl)p...)copy SMILEScopy InChI
Affinity DataKi:  1.92nMAssay Description:Binding affinity to 5HT2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1JPXPubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50029257((3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)p...)copy SMILEScopy InChI
Affinity DataKi:  47nMAssay Description:Binding affinity to adrenergic alpha1B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1JPXPubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50029257((3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)p...)copy SMILEScopy InChI
Affinity DataKi:  2.88E+3nMAssay Description:Binding affinity to 5HT1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1JPXPubMed
TargetFalcipain 2(Plasmodium falciparum)
International Center for Genetic Engineering and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50261135(CHEMBL525938 | LMNNAEHINQFYMFI)copy SMILEScopy InChI
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JZRPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193046(CHEMBL3969626)copy SMILEScopy InChI
Affinity DataKi:  5.30E+3nMAssay Description:Competitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent peptide substrate in presence of NAD+ by Lineweaver-Burk p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193046(CHEMBL3969626)copy SMILEScopy InChI
Affinity DataKi:  9.80E+3nMAssay Description:Noncompetitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by Lineweaver-Burk plot a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)TBA
LigandPNGBDBM50594991(CHEMBL415320)copy SMILES
Affinity DataIC50: 0.210nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77X7PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)TBA
LigandPNGBDBM50594992(CHEMBL316785)copy SMILES
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77X7PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)TBA
LigandPNGBDBM50594990(CHEMBL83825)copy SMILES
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77X7PubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))TBA
LigandPNGBDBM50594994(CHEMBL5193093)copy SMILES
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77X7PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193080(CHEMBL3951539)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Inhibition of full-length human N-terminal GST-tagged SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity u...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193045(CHEMBL3986181)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))TBA
LigandPNGBDBM50594993(CHEMBL5190859)copy SMILES
Affinity DataIC50: 118nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77X7PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193074(CHEMBL3933232)copy SMILEScopy InChI
Affinity DataIC50: 149nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193073(CHEMBL2397737)copy SMILEScopy InChI
Affinity DataIC50: 297nMAssay Description:Inhibition of full-length human N-terminal GST-tagged SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity u...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193076(CHEMBL3900138)copy SMILEScopy InChI
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 747 residues) expressed in Escherichia coli BL21 (DE3) using AMC-labeled p53-derived acetylated lysine ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193073(CHEMBL2397737)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)copy SMILEScopy InChI
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193080(CHEMBL3951539)copy SMILEScopy InChI
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of deacetylase activity ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50215507(6-methoxy-2,3,4,9-tetrahydro-1H-carbazole-1-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193075(CHEMBL3902988)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193081(CHEMBL271761)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human FLAG-tagged SIRT1 expressed in HEK293 cells using [3H]-H3 peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193043(CHEMBL3920465)copy SMILEScopy InChI
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant human SIRT1 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor de Lys ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193078(CHEMBL3956664)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50346551(CHEMBL1795371)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human N-terminal 6His-tagged SIRT2 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193046(CHEMBL3969626)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of recombinant human SIRT2 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50190132(CHEMBL3828225)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SIRT2 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)copy SMILEScopy InChI
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human SIRT2 using biotin labeled histone H4 peptide with an acetylated lysine 4 as substrate measured after 1 hr by luminescence analys...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193079(CHEBI:5834 | CHEMBL1237210)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50178772(6-hydroxy-2,3,4,9-tetrahydro-1H-carbazole-1-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193056(CHEMBL3980009)copy SMILEScopy InChI
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity preincubated with protein followed by addition of AMC-tagged Arg-His-Lys-Lys(Ac) (379 to...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50297159(2-(phenylamino)benzamide | CHEMBL561194)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of SIRT1 (unknown origin) using acetylated lysine as substrate by Fluor de Lys assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193043(CHEMBL3920465)copy SMILEScopy InChI
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged SIRT2 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193078(CHEMBL3956664)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50190132(CHEMBL3828225)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193079(CHEBI:5834 | CHEMBL1237210)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of recombinant human GST-tagged SIRT2 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193044(CHEMBL3942319)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity preincubated with protein followed by addition of AMC-tagged Arg-His-Lys-Lys(Ac) (379 to...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50193046(CHEMBL3969626)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human SIRT1 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of human GST-tagged SIRT1 (18 to 340 residues) expressed in Escherichia coli BL21 (DE3)LysS using acetylated HeLa histones as substrate me...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50396052(CHEMBL2170195)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human SIRT1 assessed as NAD+-dependent deacetylase activity using acetylated tubuline as substrate measured after overnight incubation ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Non-competitive inhibition of recombinant human SIRT1 using acetylated histone as substrate measured after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50346551(CHEMBL1795371)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of recombinant human SIRT1 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor de Lys ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM29040(cambinol)copy SMILEScopy InChI
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human SIRT1 expressed in bacterial expression system assessed as reduction in conversion of [3H]acetyl-H4 to [3H]acetic acid measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM29040(cambinol)copy SMILEScopy InChI
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of human GST-tagged SIRT2 expressed in bacterial expression system assessed as deacetylation activity using [3H]acetyl-H4 peptide as subst...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
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