Compile Data Set for Download or QSAR
Found 101 with Last Name = 'di marco' and Initial = 's'
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169942(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methanesu...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169930(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(cyclopropylme...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169904(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-diethylam...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169911(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169899(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169922(3-Cyclohexyl-1-[2-(4-diethylamino-piperidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169906(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169915(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(1,1-dioxo-1...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169903(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(isopropyl-met...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169920(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methyl-pi...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169931(2-(4-Chloro-phenyl)-3-cyclohexyl-1-{[methyl-(1-met...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169919(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-dimethyla...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35570(1H-benzo[de]isoquinoline-1,3(2H)-dione, 19)copy SMILEScopy InChI
Affinity DataIC50: 14nM EC50:  2.20E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein [2420-2989,M2833T,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169932(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(dimethylcarba...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169921(3-Cyclohexyl-2-[3-(3,3-difluoro-piperidin-1-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169916(3-Cyclohexyl-1-{[methyl-(1-methyl-piperidin-3-ylme...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169929(2-Cyclohex-1-enyl-3-cyclohexyl-1-[2-(4-dimethylami...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169910(3-Cyclohexyl-1-[2-(4-methanesulfonyl-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35563(1H-benzo[de]isoquinoline-1,3(2H)-dione, 12)copy SMILEScopy InChI
Affinity DataIC50: 19nM EC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 20nM EC50:  7.10E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-2989,P2914A,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35560(1H-benzo[de]isoquinoline-1,3(2H)-dione, 9)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35558(1H-benzo[de]isoquinoline-1,3(2H)-dione, 7)copy SMILEScopy InChI
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35569(1H-benzo[de]isoquinoline-1,3(2H)-dione, 18)copy SMILEScopy InChI
Affinity DataIC50: 30nM EC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169927(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-furan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169933(3-Cyclohexyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein [2420-2989,P2914A,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169898(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35571(1H-benzo[de]isoquinoline-1,3(2H)-dione, 20 | cis-i...)copy SMILEScopy InChI
Affinity DataIC50: 42nM EC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 2b (isolate HC-J8) (HCV...)
IRBM-MRL Rome

LigandPNGBDBM35570(1H-benzo[de]isoquinoline-1,3(2H)-dione, 19)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169907(3-Cyclohexyl-1-[2-(1,1-dioxo-1lambda*6*-thiomorpho...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169938(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169908(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162102(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169946(3-Cyclohexyl-1-[(isopropyl-methyl-carbamoyl)-methy...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169924(3-Cyclohexyl-1-[(cyclopropylmethyl-carbamoyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35567(1H-benzo[de]isoquinoline-1,3(2H)-dione, 16)copy SMILEScopy InChI
Affinity DataIC50: 66nM EC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169928(3-Cyclopentyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169917(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-(6-methox...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169918(3-Cyclohexyl-1-[2-(4-dimethylamino-pyrrolidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169912(2,3-Dicyclohexyl-1-[2-(4-dimethylamino-piperidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169905(3-Cyclopentyl-1-[2-(4-dimethylamino-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169913(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-{3-[(isop...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein [2420-2989,M2833T,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 78nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169900(2-(4-Chloro-3-dimethylaminomethyl-phenyl)-3-cycloh...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 2b (isolate HC-J8) (HCV...)
IRBM-MRL Rome

LigandPNGBDBM35566(1H-benzo[de]isoquinoline-1,3(2H)-dione, 15)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169901(3-Cyclohexyl-1-[(dimethylcarbamoylmethyl-methyl-ca...)copy SMILEScopy InChI
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
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