Compile Data Set for Download or QSAR
Found 662 with Last Name = 'eathiraj' and Initial = 's'
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 0.370nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)copy SMILES
Affinity DataIC50: 0.390nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499810(N-((S)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...)copy SMILES
Affinity DataIC50: 0.770nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 0.790nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)copy SMILES
Affinity DataIC50: 0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)copy SMILES
Affinity DataIC50: 0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499838((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((R)-1- ...)copy SMILES
Affinity DataIC50: 0.930nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499976((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)copy SMILES
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499869(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)copy SMILES
Affinity DataIC50: 0.980nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499924(N-(4-chloro-3-(4-(((3R,6S)-6- (hydroxymethyl)tetra...)copy SMILES
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499974((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)copy SMILES
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499890((S)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...)copy SMILES
Affinity DataIC50: 1nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499991(US11020398, Compound I-360e | racemic-cis-(2-chlor...)copy SMILES
Affinity DataIC50: 1.07nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499854((4-(((3R,6S)-6-((S)-1- aminoethyl)tetrahydro-2H-py...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499892(N-((S)-1-((2S,5R)-5-((5-(2-methyl-4- phenoxybenzoy...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499881((S)-N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-p...)copy SMILES
Affinity DataIC50: 1.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499839(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499855((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((S)-1- ...)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499888((2-chloro-4-phenoxyphenyl)(4-((cis-4- hydroxy-4-me...)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499891(2-hydroxy-2-methyl-N-(cis-4-((5-(4- phenoxybenzoyl...)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499882(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499889((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxy-4-...)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499870((2-chloro-4-(3- fluorophenoxy)phenyl)(4-(((3R,6S)-...)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499893(N-(((2S,5R)-5-((5-(4-phenoxybenzoyl)- 7H-pyrrolo[2...)copy SMILES
Affinity DataIC50: 1.60nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499885((4-(((3R,6S)-6-((R)-1- hydroxyethyl)tetrahydro-2H-...)copy SMILES
Affinity DataIC50: 1.60nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499815(N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)-7H-...)copy SMILES
Affinity DataIC50: 1.63nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499857((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxycyc...)copy SMILES
Affinity DataIC50: 1.70nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499865((2-chloro-4-phenoxyphenyl)(4-((trans- 4-((dimethyl...)copy SMILES
Affinity DataIC50: 1.70nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499876((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-(2-hydro...)copy SMILES
Affinity DataIC50: 1.70nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499867(US11020398, Compound I-179 | rac-(2-chloro-4-pheno...)copy SMILES
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499894((R)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...)copy SMILES
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499868(US11020398, Compound I-180 | rac-(2-chloro-4-pheno...)copy SMILES
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50536168(CHEMBL4574111)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length unphosphorylated AKT1 (1 to 480 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN3CCMPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499739(1-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3-d]p...)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499904((R)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499898((S)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499790(N-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3-d]p...)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499731((2-chlorophenyl)(4-((cis-4- (methylamino)cyclohexy...)copy SMILES
Affinity DataIC50: 2.10nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499866((2-chloro-4-phenoxyphenyl)(4-((cis-4- ((dimethylam...)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499757((2-chlorophenyl)(4-((cis-4-(pyrrolidin- 1-yl)cyclo...)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499829((4-((cis-4-aminocyclohexyl)amino)-7H- pyrrolo[2,3-...)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499883(N-((R)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499871((2-chloro-4-(3- chlorophenoxy)phenyl)(4-(((3R,6S)-...)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50536169(CHEMBL4519558)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full length active AKT1 (1 to 480 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-GRPRTSSFAE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN3CCMPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499773((S)-N-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3...)copy SMILES
Affinity DataIC50: 2.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499827(N-(cis-4-((5-(4-phenoxybenzoyl)-7H- pyrrolo[2,3-d]...)copy SMILES
Affinity DataIC50: 2.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 2.40nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ArQule, Inc.

US Patent
LigandPNGBDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)copy SMILES
Affinity DataIC50: 2.40nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ0CFCUS Patent
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