Compile Data Set for Download or QSAR
Found 99 with Last Name = 'honda' and Initial = 's'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50520336(CHEMBL4470042)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521882(CHEMBL4469155)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521887(CHEMBL4459939)copy SMILEScopy InChI
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521879(CHEMBL4559232)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543597(CHEMBL4641405)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521881(CHEMBL4438197)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521873(CHEMBL4469276)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543590(CHEMBL4637787)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538942(CHEMBL4645181)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521889(CHEMBL4449044)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543598(CHEMBL4635315)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521877(CHEMBL4465053)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543586(CHEMBL4644441)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521878(CHEMBL4524228)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521866(CHEMBL4460300)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521883(CHEMBL4520479)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543593(CHEMBL4645370)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538943(CHEMBL4640097)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538943(CHEMBL4640097)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543592(CHEMBL4634925)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543587(CHEMBL4647793)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521871(CHEMBL4461942)copy SMILEScopy InChI
Affinity DataIC50: 105nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521880(CHEMBL4468202)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521872(CHEMBL4524529)copy SMILEScopy InChI
Affinity DataIC50: 138nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538938(CHEMBL4641905)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538937(CHEMBL4648092)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543591(CHEMBL4640988)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538936(CHEMBL4635555)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543589(CHEMBL4634681)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543588(CHEMBL4633268)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538939(CHEMBL4644422)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521886(CHEMBL4550931)copy SMILEScopy InChI
Affinity DataIC50: 275nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521876(CHEMBL4463877)copy SMILEScopy InChI
Affinity DataIC50: 279nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521885(CHEMBL4459061)copy SMILEScopy InChI
Affinity DataIC50: 292nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521869(CHEMBL4446268)copy SMILEScopy InChI
Affinity DataIC50: 294nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50037205(CHEMBL3356239)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9XVPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538935(CHEMBL4632774)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50452825(CHEMBL4216742)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Modulatory activity against gamma-secretase in human SK-N-BE(2) cells assessed as reduction in amyloid beta 42 production after 6 hrs by sandwich ELI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78HTVPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50543595(CHEMBL4634006)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N8RPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538941(CHEMBL4649432)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521875(CHEMBL4464323)copy SMILEScopy InChI
Affinity DataIC50: 416nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521884(CHEMBL4440765)copy SMILEScopy InChI
Affinity DataIC50: 441nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538940(CHEMBL4638711)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538924(CHEMBL4649486)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50037212(CHEMBL3356251)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9XVPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50452832(CHEMBL4209239)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Modulatory activity against gamma-secretase in human SK-N-BE(2) cells assessed as reduction in amyloid beta 42 production after 6 hrs by sandwich ELI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78HTVPubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50140241(Allopurinol | Aloral | Aluline 100 | Aluline 300 |...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid production using xanthine as substrate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6VJMPubMed
TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50538932(CHEMBL4647839)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3WWPPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521888(CHEMBL4453723)copy SMILEScopy InChI
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6H9KPubMed
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