Compile Data Set for Download or QSAR
Found 1159 with Last Name = 'nanthakumar' and Initial = 's'
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)copy SMILEScopy InChI
Affinity DataKi: <1nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463499(CHEMBL4250547)copy SMILEScopy InChI
Affinity DataKi: <1nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549385(CHEMBL4777515)copy SMILES
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50044287(CHEMBL3356900)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex

LigandPNGBDBM35653(pyrimidylpyrrole, 11a)copy SMILEScopy InChI
Affinity DataKi: <2nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463481(CHEMBL4244717)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463492(CHEMBL4241305)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463500(CHEMBL4243658)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463498(CHEMBL4241959)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex

LigandPNGBDBM35647(erk000636 | pyrimidylpyrrole, 9f)copy SMILEScopy InChI
Affinity DataKi: <2nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35663(pyrimidylpyrrole, 11k)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35662(pyrimidylpyrrole, 11j)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35660(pyrimidylpyrrole, 11h)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35659(pyrimidylpyrrole, 11g)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35657(pyrimidylpyrrole, 11e)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35654(erk000526 | pyrimidylpyrrole, 11b)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35653(pyrimidylpyrrole, 11a)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35651(pyrimidylpyrrole, 10d)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35650(pyrimidylpyrrole, 10c)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35649(erk000537 | pyrimidylpyrrole, 10b)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35645(pyrimidylpyrrole, 9d)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35643(pyrimidylpyrrole, 9b)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35642(pyrimidylpyrrole, 9a)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35641(erk000040 | pyrimidylpyrrole, 2)copy SMILEScopy InChI
Affinity DataKi: <2nM ΔG°: <-50.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35665(erk000617 | pyrimidylpyrrole, 11m)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50274571(CHEMBL4127784)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463495(CHEMBL4244623)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463489(CHEMBL4245089)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463490(CHEMBL4240605)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463491(CHEMBL4245197)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549387(CHEMBL4752045)copy SMILES
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549388(CHEMBL4742150)copy SMILES
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549386(CHEMBL4778806)copy SMILES
Affinity DataKi:  3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50274537(CHEMBL4129974)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98BK8PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549393(CHEMBL4757625)copy SMILES
Affinity DataKi:  4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)copy SMILEScopy InChI
Affinity DataKi: <4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50275934((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4VZTPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50274538(CHEMBL4126773)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98BK8PubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35647(erk000636 | pyrimidylpyrrole, 9f)copy SMILEScopy InChI
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35646(erk000506 | pyrimidylpyrrole, 9e)copy SMILEScopy InChI
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35658(erk000651 | pyrimidylpyrrole, 11f)copy SMILEScopy InChI
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)copy SMILEScopy InChI
Affinity DataKi: <5nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50549401(CHEMBL4788786)copy SMILES
Affinity DataKi:  5nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex

LigandPNGBDBM35649(erk000537 | pyrimidylpyrrole, 10b)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2805665PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463494(CHEMBL4240883)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex

LigandPNGBDBM35656(erk000650 | pyrimidylpyrrole, 11d)copy SMILEScopy InChI
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798SSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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