Compile Data Set for Download or QSAR
Found 291 with Last Name = 'trumpp-kallmeyer' and Initial = 's'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3624(5-[(3-Bromophenyl)amino]-1-methylpyrazolo[4,3-g]-q...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3583(5-[(3-Bromophenyl)amino]-1H-pyrrolo[3,2-g]quinazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.440nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3582(5-[(3-Bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.440nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6266(8-Cyclopentyl-2-[4-(2-diethylaminoethoxy)phenylami...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3642(2-[({4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]qui...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3630(5-[(3-Bromophenyl)amino]-1-methylpyrrolo[3,2-g]-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3631(3-{4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quina...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3638(5-[(3-Bromophenyl)amino]-3-[(N,N-dimethylamino)-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3641(5-[(3-Bromophenyl)amino]-3-[[N-(carboxymethyl)-N-m...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3637(2-[({4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]qui...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3627(5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3634(5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6268(8-Cycloheptyl-2-[4-(2-diethylaminoethoxy)phenylami...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3639(5-[(3-Bromophenyl)amino]-3-[(4-morpholino)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3636(2-{4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quina...)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6277(8-Bicyclo[2.2.1]hept-2-yl-2-[4-(4-methylpiperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3640(5-[(3-Bromophenyl)amino]-3-[(N,N,N-trimethylethyle...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6280(8-Bicyclo[2.2.1]hept-2-yl-2-{4-[4-(3-hydroxypropyl...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3635(5-[(3-Bromophenyl)amino]-1-[3-(4-morpholino)propyl...)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3095(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 | 6-(2,...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3101(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 | 6-(2,...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3104(2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6267(8-Cyclohexyl-2-[4-(2-diethylaminoethoxy)phenylamin...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3625(3-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quin...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6275(8-(3-methylbutyl)-2-{[4-(4-methylpiperazin-1-yl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3633(5-[(3-Bromophenyl)amino]-1-[3-(N,N-dimethylamino)-...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM50064349(1-tert-Butyl-3-{6-(2,6-dichloro-phenyl)-2-[4-(2-di...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3071(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3473(1-benzyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert Company

Curated by ChEMBL
LigandPNGBDBM3474(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0KQ6PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6279(8-Cyclopentyl-2-{4-[4-(3-hydroxypropyl)piperidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6250(8-Butyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6256(8-Bicyclo[2.2.1]hept-2-yl-2-phenylamino-8H-pyrido[...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3626(5-[(3-Bromophenyl)amino]-1-[2-(N,N-dimethylamino)e...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3632(5-[(3-Bromophenyl)amino]-1-[2-(N,N-dimethylamino)-...)copy SMILEScopy InChI
Affinity DataIC50: 41nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6265(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6254(8-Cyclohexyl-2-phenylamino-8H-pyrido[2,3-d]pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6248(2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3628(2-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quin...)copy SMILEScopy InChI
Affinity DataIC50: 53nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1HRQPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6250(8-Butyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
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