Affinity DataIC50: 2.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 13nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 18nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Bcl-xL/BAK (unknown origin) interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of Bcl-xL/BAK (unknown origin) interactionMore data for this Ligand-Target Pair
In DepthDetails
TargetBcl-2-like protein 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of Bcl-xL/BAK (unknown origin) interactionMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
AbbVie S.á.r.l.; Galapagos NV
US Patent
AbbVie S.á.r.l.; Galapagos NV
US Patent
Affinity DataIC50: 40nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of Bcl-xL/BAK (unknown origin) interactionMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Novartis Institutes for BioMedical Research Inc.
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of Bcl-xL/BAK (unknown origin) interactionMore data for this Ligand-Target Pair
In DepthDetails