Found 21 with Last Name = 'aaronson' and Initial = 'sa' TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human TNKS-1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Mus musculus)
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Mus musculus)
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 181nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human TNKS-2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 283nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 685nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 707nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataIC50: 832nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PARP-2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Universit£ degli Studi di Perugia
Curated by ChEMBL
Universit£ degli Studi di Perugia
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PARP-1More data for this Ligand-Target Pair
