TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Binding affinity to biotinylated human CAR LBD after 1 hr by Scintillation Proximity AssayMore data for this Ligand-Target Pair
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TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails
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TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails
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TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetCytochrome P450 3A5(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...More data for this Ligand-Target Pair
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TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inverse agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails
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TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...More data for this Ligand-Target Pair
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