Compile Data Set for Download or QSAR
Found 91 with Last Name = 'yoder' and Initial = 'sc'
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251959(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50264220(2-(1,6-diphenyl-1H-imidazo[4,5-c]pyridine-4-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2WB7PubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93422(PHD Inhibitor, 12{1,1,2})copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93422(PHD Inhibitor, 12{1,1,2})copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93425(PHD Inhibitor, 12{4,1,2})copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93430(PHD Inhibitor, 12{2,1,2})copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93426(PHD Inhibitor, 12{2,5,2})copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93426(PHD Inhibitor, 12{2,5,2})copy SMILEScopy InChI
Affinity DataIC50: 8.90nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93427(PHD Inhibitor, 12{2,6,2})copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251958(2-(2-(2-(benzylsulfonyl)acetamido)-3-hydroxy-2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 11.7nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 12.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)copy SMILEScopy InChI
Affinity DataIC50: 12.9nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)copy SMILEScopy InChI
Affinity DataIC50: 13.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 13.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93425(PHD Inhibitor, 12{4,1,2})copy SMILEScopy InChI
Affinity DataIC50: 13.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93430(PHD Inhibitor, 12{2,1,2})copy SMILEScopy InChI
Affinity DataIC50: 13.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93432(PHD Inhibitor, 12{2,6,4})copy SMILEScopy InChI
Affinity DataIC50: 14.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)copy SMILEScopy InChI
Affinity DataIC50: 14.6nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93427(PHD Inhibitor, 12{2,6,2})copy SMILEScopy InChI
Affinity DataIC50: 16.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93432(PHD Inhibitor, 12{2,6,4})copy SMILEScopy InChI
Affinity DataIC50: 16.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93433(PHD Inhibitor, 12{2,1,4})copy SMILEScopy InChI
Affinity DataIC50: 18.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50252002(2-(2-(2-(4-tert-butylphenylsulfonyl)acetamido)-3-h...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251957(CHEMBL519615 | {2-[2-(Biphenyl-4-sulfonyl)-acetyli...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251908(2-(3-hydroxy-2-(2-(naphthalen-2-ylsulfonyl)acetami...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93420(PHD Inhibitor, 12{3,1,4})copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251907(2-(2-(2-(4-chlorophenylsulfonyl)acetamido)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93422(PHD Inhibitor, 12{1,1,2})copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 37.4nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})copy SMILEScopy InChI
Affinity DataIC50: 38.3nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93418(PHD Inhibitor, 12{2,3,1})copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93425(PHD Inhibitor, 12{4,1,2})copy SMILEScopy InChI
Affinity DataIC50: 41.9nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93426(PHD Inhibitor, 12{2,5,2})copy SMILEScopy InChI
Affinity DataIC50: 44.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93418(PHD Inhibitor, 12{2,3,1})copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50252001(2-(3-hydroxy-2-(2-tosylacetamido)-2,3-dihydrothiaz...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetProlyl hydroxylase EGLN2(Human)
Amgen, Inc.

LigandPNGBDBM93433(PHD Inhibitor, 12{2,1,4})copy SMILEScopy InChI
Affinity DataIC50: 60.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50264219(2-(6-chloro-1-phenyl-1H-imidazo[4,5-c]pyridine-4-c...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2WB7PubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93427(PHD Inhibitor, 12{2,6,2})copy SMILEScopy InChI
Affinity DataIC50: 67.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251900(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50251905(2-(2-(2-(2-chlorophenylsulfonyl)acetamido)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JM5PubMed
TargetProlyl hydroxylase EGLN3(Human)
Amgen, Inc.

LigandPNGBDBM93420(PHD Inhibitor, 12{3,1,4})copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)copy SMILEScopy InChI
Affinity DataIC50: 86.4nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)copy SMILEScopy InChI
Affinity DataIC50: 90.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
TargetEgl nine homolog 1(Human)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM93430(PHD Inhibitor, 12{2,1,2})copy SMILEScopy InChI
Affinity DataIC50: 93.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27SXPPubMed
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