Compile Data Set for Download or QSAR
Found 306 with Last Name = 'dattoli' and Initial = 'sd'
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))TBA
LigandPNGBDBM50550223(CHEMBL4794300)copy SMILES
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50439683(CHEMBL2418221)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMAssay Description:Inhibition of alphaVbeta3 integrin-mediated human SK-MEL-24 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50439683(CHEMBL2418221)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:Antagonist activity at alpha5beta1 in human K562 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibrone...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))TBA
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505781(CHEMBL4461668)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50021394(CHEMBL3289605)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505781(CHEMBL4461668)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50505779(CHEMBL4461771)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))TBA
LigandPNGBDBM50505779(CHEMBL4461771)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))TBA
LigandPNGBDBM50021393(CHEMBL3289604)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46HMPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50021393(CHEMBL3289604)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550224(CHEMBL4797755)copy SMILES
Affinity DataIC50: 5.5nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50021393(CHEMBL3289604)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))TBA
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of fibrinogen binding to alpha2bbeta3 isolated from human HEL cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4NSNPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550222(CHEMBL4777693)copy SMILES
Affinity DataIC50: 7.60nMAssay Description:Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46HMPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550222(CHEMBL4777693)copy SMILES
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))TBA
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at alpha2bbeta3 in human HEL cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550223(CHEMBL4794300)copy SMILES
Affinity DataIC50: 9.70nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505772(CHEMBL4589062)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based com...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)copy SMILES
Affinity DataIC50: 9.90nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50498365(CHEMBL3590531)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human alpha4beta1integrin in human Jurkat cells assessed as reduction of VCAM-1-induced ERK1/2 phosphorylation after 60 mins b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4NSNPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50498365(CHEMBL3590531)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4NSNPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550225(CHEMBL4764510)copy SMILES
Affinity DataIC50: 12nMAssay Description:Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))TBA
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))TBA
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550225(CHEMBL4764510)copy SMILES
Affinity DataIC50: 17nMAssay Description:Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50439689(CHEMBL2418214)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of alpha5beta1 integrin-mediated human K562 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))TBA
LigandPNGBDBM50550225(CHEMBL4764510)copy SMILES
Affinity DataIC50: 23nMAssay Description:Inhibition of fibronectin binding to alphaVbeta6 isolated form human HT-29 cells incubated for 1 hr by scintillation-proximity assay based competitiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50222360(Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Antagonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50222360(Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Antagonist activity at alphavbeta3 integrin in human SK-MEL-24 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75HWXPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))TBA
LigandPNGBDBM50439683(CHEMBL2418221)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50550225(CHEMBL4764510)copy SMILES
Affinity DataIC50: 36nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50222359(2-{[1-(4-aminobutyl)-4-methyl-2-oxo-6-phenyl-1,2,5...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of alphaVbeta3 integrin-mediated human SK-MEL-24 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50505779(CHEMBL4461771)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Antagonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50222359(2-{[1-(4-aminobutyl)-4-methyl-2-oxo-6-phenyl-1,2,5...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of alpha5beta1 integrin-mediated human K562 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))TBA
LigandPNGBDBM50550225(CHEMBL4764510)copy SMILES
Affinity DataIC50: 44nMAssay Description:Antagonist activity at alphaVbeta6 in human HT-29 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibron...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505782(CHEMBL4586928)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50222357(3-(((R)-1-((S)-1-(4-aminophenyl)ethyl)-4-methyl-2-...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of alpha5beta1 integrin-mediated human K562 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50498364(CHEMBL3590533)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4NSNPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50222357(3-(((R)-1-((S)-1-(4-aminophenyl)ethyl)-4-methyl-2-...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Inhibition of alphaVbeta3 integrin-mediated human SK-MEL-24 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z45VCPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)copy SMILES
Affinity DataIC50: 72nMAssay Description:Antagonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50447509(CHEMBL3115407)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46HMPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))TBA
LigandPNGBDBM50021393(CHEMBL3289604)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Inhibition of fibronectin binding to alphaVbeta6 isolated form human HT-29 cells incubated for 1 hr by scintillation-proximity assay based competitiv...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154MPKPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50447508(CHEMBL3115406)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46HMPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50447509(CHEMBL3115407)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46HMPubMed
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