Compile Data Set for Download or QSAR
Found 88 with Last Name = 'bucknell' and Initial = 'sj'
LigandPNGBDBM391716(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)copy SMILES
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391716(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)copy SMILES
Affinity DataKi:  0.0200nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391716(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)copy SMILES
Affinity DataKi:  0.0200nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391727(N-[(2R)-1-({(2S)-3-{1-[2- | US10300056, Example 12...)copy SMILES
Affinity DataKi:  0.0250nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391727(N-[(2R)-1-({(2S)-3-{1-[2- | US10300056, Example 12...)copy SMILES
Affinity DataKi:  0.0250nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
LigandPNGBDBM50539955(CHEMBL4638938)copy SMILEScopy InChI
Affinity DataKi:  0.0251nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)copy SMILES
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)copy SMILEScopy InChI
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)copy SMILES
Affinity DataKi:  0.0320nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)copy SMILES
Affinity DataKi:  0.0320nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
LigandPNGBDBM391723(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)copy SMILES
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391719(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 4 | ...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391722(N-[(2R)-1-({(2S)-3-(1- | US10300056, Example 7 | U...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391719(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 4 | ...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391723(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391723(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391722(N-[(2R)-1-({(2S)-3-(1- | US10300056, Example 7 | U...)copy SMILES
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312053(5-{1'-[(2R)-3-(7-methyl-1H-indazol-5-yl)-2-({[4-(2...)copy SMILES
Affinity DataKi:  0.0500nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM311886(N-[(2R)-1-[4-(1H-imidazol-2-yl)-1,4'-bipiperidin-1...)copy SMILES
Affinity DataKi:  0.0500nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391725(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)copy SMILES
Affinity DataKi:  0.0630nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312050(US10166226, Example 6 | ethyl 5-{1'-[(2R)-3-(7-met...)copy SMILES
Affinity DataKi:  0.0630nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391720(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 5...)copy SMILES
Affinity DataKi:  0.0630nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391725(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)copy SMILES
Affinity DataKi:  0.0630nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391720(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 5...)copy SMILES
Affinity DataKi:  0.0630nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
LigandPNGBDBM391725(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)copy SMILES
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391729(3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example...)copy SMILEScopy InChI
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391724(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)copy SMILEScopy InChI
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391718(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)copy SMILES
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM311913(N-[(2R)-1-[4-(4-methyl-1H-imidazol-5-yl)-1,4'-bipi...)copy SMILES
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391729(3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example...)copy SMILEScopy InChI
Affinity DataKi:  0.0790nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391724(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)copy SMILEScopy InChI
Affinity DataKi:  0.0790nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391718(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)copy SMILES
Affinity DataKi:  0.0790nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
LigandPNGBDBM391724(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)copy SMILEScopy InChI
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
LigandPNGBDBM391718(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)copy SMILES
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391717(US10300056, Example 2 | US10888561, Example 2 | te...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391717(US10300056, Example 2 | US10888561, Example 2 | te...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391728(3-(4-{(2S)-2-{[(2R)-3-(7- | US10300056, Example 13...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391721(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | ...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391728(3-(4-{(2S)-2-{[(2R)-3-(7- | US10300056, Example 13...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4T1XUS Patent
LigandPNGBDBM50539954(CHEMBL4636143)copy SMILEScopy InChI
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3JKRPubMed
TargetReceptor activity-modifying protein 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM391721(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | ...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T155ZXUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312052(N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(5-methy...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312002(N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(4-methy...)copy SMILES
Affinity DataKi:  0.100nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312049(4-(7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-N-{(2R...)copy SMILES
Affinity DataKi:  0.126nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM312051(N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-[4-(4...)copy SMILES
Affinity DataKi:  0.158nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetCalcitonin gene-related peptide 1(Homo sapiens (Human))
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM311965(N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-[4-(1...)copy SMILES
Affinity DataKi:  0.158nMAssay Description:Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28C9ZBCUS Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)copy SMILEScopy InChI
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474F8RPubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701(CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-be...)copy SMILEScopy InChI
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)copy SMILEScopy InChI
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)copy SMILEScopy InChI
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474F8RPubMed
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