Compile Data Set for Download or QSAR
Found 98 with Last Name = 'cacatian' and Initial = 'st'
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29957(piperidine-1-carboxamide, 21t)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29950(piperidine-1-carboxamide, 21m)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29956(piperidine-1-carboxamide, 21s)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)copy SMILEScopy InChI
Affinity DataIC50: 0.470nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306433(CHEMBL601211 | N-(adamantan-2-yl)-7-bromo-3-(carba...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306416(CHEMBL596620 | N-(adamantan-2-yl)-1,3-dihydrospiro...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306417(CHEMBL596621 | N-(adamantan-2-yl)-2,3-dihydrospiro...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306414(3-Phenyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306415(4-Phenyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306433(CHEMBL601211 | N-(adamantan-2-yl)-7-bromo-3-(carba...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29959(piperidine-1-carboxamide, 21v)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306411(3-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306431(2-[(3R)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306412(4-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306410(2-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306429(2-{1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306434(CHEMBL606420 | N-(adamantan-2-yl)-7-bromo-3-(2-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306432(CHEMBL601210 | N-(adamantan-2-yl)-7-bromo-3-[(meth...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306428(2-{1'-[(adamantan-2-yl)carbamoyl]-7-chloro-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306413(2-Phenyl-piperidine-1-carboxylic acid adamantan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306431(2-[(3R)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29945(piperidine-1-carboxamide, 21h)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306417(CHEMBL596621 | N-(adamantan-2-yl)-2,3-dihydrospiro...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29948(piperidine-1-carboxamide, 21k)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306427(2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306422(2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306426(2-{1'-[(adamantan-2-yl)carbamoyl]-5-chloro-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29958(piperidine-1-carboxamide, 21u)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29944(piperidine-1-carboxamide, 21g)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29935(piperidine-1-carboxamide, 7i)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306429(2-{1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29929(piperidine-1-carboxamide, 7c)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29954(piperidine-1-carboxamide, 21q)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306423(2-{1'-[(adamantan-2-yl)carbamoyl]-5-methyl-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29941(piperidine-1-carboxamide, 21d)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29952(piperidine-1-carboxamide, 21o)copy SMILEScopy InChI
Affinity DataIC50: 7nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29943(piperidine-1-carboxamide, 21f)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306425(2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306424(2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29946(piperidine-1-carboxamide, 21i)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306423(2-{1'-[(adamantan-2-yl)carbamoyl]-5-methyl-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306428(2-{1'-[(adamantan-2-yl)carbamoyl]-7-chloro-2,3-dih...)copy SMILEScopy InChI
Affinity DataIC50: 10.7nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29936(piperidine-1-carboxamide, 7j)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29947(piperidine-1-carboxamide, 21j)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29942(piperidine-1-carboxamide, 21e)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21VXVPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306421(2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro...)copy SMILEScopy InChI
Affinity DataIC50: 16.1nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306409(CHEMBL596815 | Piperidine-1-carboxylic acid adaman...)copy SMILEScopy InChI
Affinity DataIC50: 16.1nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9BWZPubMed
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