Compile Data Set for Download or QSAR
Found 115 with Last Name = 'ley' and Initial = 'sv'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086246(CHEMBL3425758)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Durham University

Curated by ChEMBL
LigandPNGBDBM50248034(2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-ph...)copy SMILEScopy InChI
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M09B6PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086248(CHEMBL3425756)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086249(CHEMBL3425755)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086250(CHEMBL3425759)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22R3S5QPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086252(CHEMBL3425762)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086247(CHEMBL3425757)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086251(CHEMBL3425760)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of matrix metalloprotease 2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22R3S5QPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086245(CHEMBL3425761)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)copy SMILEScopy InChI
Affinity DataKi:  33nMAssay Description:Inhibition of matrix metalloprotease 1More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50086253(CHEMBL3425763)copy SMILEScopy InChI
Affinity DataKi:  35nMAssay Description:Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4CZWPubMed
TargetStromelysin-1(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)copy SMILEScopy InChI
Affinity DataKi:  43nMAssay Description:Inhibition of matrix metalloprotease 3More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22R3S5QPubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0JPZPubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0JPZPubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0JPZPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 116nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 141nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116890(CHEMBL3613038)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116902(CHEMBL3613026)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116895(CHEMBL3613033)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetSortilin(Homo sapiens (Human))
Durham University

Curated by ChEMBL
LigandPNGBDBM50248034(2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-ph...)copy SMILEScopy InChI
Affinity DataIC50: 238nMAssay Description:Binding affinity to NTR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M09B6PubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 311nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 468nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116903(CHEMBL3613025)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMedDrugBank
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116891(CHEMBL3613037)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 701nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116904(CHEMBL3613024)copy SMILEScopy InChI
Affinity DataIC50: 920nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116899(CHEMBL3613029)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMedDrugBank
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116905(CHEMBL3613023)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetCREB-binding protein(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)copy SMILEScopy InChI
Affinity DataIC50: 2.44E+3nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0JPZPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116889(CHEMBL3613039)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116896(CHEMBL3613032)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116895(CHEMBL3613033)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116897(CHEMBL3613031)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50184973(CHEMBL3822828)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3TKHPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116896(CHEMBL3613032)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50184975(CHEMBL3823214)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3TKHPubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50184974(CHEMBL3823057)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3TKHPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116898(CHEMBL3613030)copy SMILEScopy InChI
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116892(CHEMBL3613036)copy SMILEScopy InChI
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116897(CHEMBL3613031)copy SMILEScopy InChI
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50437329(CHEMBL2407630)copy SMILEScopy InChI
Affinity DataIC50: 7.70E+3nMAssay Description:Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux compound preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ12DDPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50116901(CHEMBL3613027)copy SMILEScopy InChI
Affinity DataIC50: 8.23E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MDPPubMed
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