Compile Data Set for Download or QSAR
Found 317 with Last Name = 'eguchi' and Initial = 't'
Target3-isopropylmalate dehydrogenase(Thermus thermophilus)
Tokyo Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50481232(CHEMBL602786)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Inhibition of Thermus thermophilus HB8 IPMDH assessed as formation of NADH by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377CHWPubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23215(Homoisocitrate thia analogue, 3 | trisodium (2S,3S...)copy SMILEScopy InChI
Affinity DataKi:  97nM ΔG°:  -41.5kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99D8PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23213(Homoisocitrate oxa analogue, 2 | trisodium (2S,3R)...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+4nM ΔG°:  -29.6kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99D8PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23216(3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid | ...)copy SMILEScopy InChI
Affinity DataKi:  1.20E+4nM ΔG°:  -29.1kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99D8PubMed
TargetSolute carrier family 22 member 8(Rattus norvegicus)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50009999(CHEMBL461 | N-benzoylglycine)copy SMILEScopy InChI
Affinity DataKi:  1.90E+4nMAssay Description:TP_TRANSPORTER: inhibition of benzylpenicillin uptake in Oat3-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026N5PubMed
TargetSolute carrier family 22 member 8(Homo sapiens (Human))
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50009999(CHEMBL461 | N-benzoylglycine)copy SMILEScopy InChI
Affinity DataKi:  3.10E+4nMAssay Description:TP_TRANSPORTER: inhibition of benzylpenicillin uptake in OAT3-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026N5PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23220((1R,2Z)-1-hydroxypent-2-ene-1,2,5-tricarboxylic ac...)copy SMILEScopy InChI
Affinity DataKi:  7.20E+4nM ΔG°:  -24.5kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase(Deinococcus radiodurans)
Tokyo Institute of Technology

LigandPNGBDBM23221((2S,3R)-2-ethenyl-3-hydroxybutanedioic acid | Viny...)copy SMILEScopy InChI
Affinity DataKi:  8.80E+4nM ΔG°:  -23.4kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase(Deinococcus radiodurans)
Tokyo Institute of Technology

LigandPNGBDBM23220((1R,2Z)-1-hydroxypent-2-ene-1,2,5-tricarboxylic ac...)copy SMILEScopy InChI
Affinity DataKi:  2.60E+5nM ΔG°:  -20.7kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetSolute carrier family 22 member 8(Homo sapiens (Human))
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50420240(CHEMBL2074590)copy SMILEScopy InChI
Affinity DataKi:  4.91E+5nMAssay Description:TP_TRANSPORTER: inhibition of benzylpenicillin uptake in OAT3-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026N5PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23218((2R,3Z)-2-hydroxy-3-(3-hydroxypropylidene)butanedi...)copy SMILEScopy InChI
Affinity DataKi:  5.10E+5nM ΔG°:  -19.5kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetSolute carrier family 22 member 8(Rattus norvegicus)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50420240(CHEMBL2074590)copy SMILEScopy InChI
Affinity DataKi:  5.82E+5nMAssay Description:TP_TRANSPORTER: inhibition of benzylpenicillin uptake in Oat3-expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026N5PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23219((1R,2E)-1-hydroxypent-2-ene-1,2,5-tricarboxylic ac...)copy SMILEScopy InChI
Affinity DataKi:  7.90E+5nM ΔG°:  -18.4kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase, mitochondrial(Saccharomyces cerevisiae)
Tokyo Institute of Technology

LigandPNGBDBM23217((2R,3E)-2-hydroxy-3-(3-hydroxypropylidene)butanedi...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+6nM ΔG°:  -16.9kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase(Deinococcus radiodurans)
Tokyo Institute of Technology

LigandPNGBDBM23219((1R,2E)-1-hydroxypent-2-ene-1,2,5-tricarboxylic ac...)copy SMILEScopy InChI
Affinity DataKi:  3.10E+6nM ΔG°:  -14.5kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase(Deinococcus radiodurans)
Tokyo Institute of Technology

LigandPNGBDBM23217((2R,3E)-2-hydroxy-3-(3-hydroxypropylidene)butanedi...)copy SMILEScopy InChI
Affinity DataKi:  5.20E+6nM ΔG°:  -13.2kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetHomoisocitrate dehydrogenase(Deinococcus radiodurans)
Tokyo Institute of Technology

LigandPNGBDBM23218((2R,3Z)-2-hydroxy-3-(3-hydroxypropylidene)butanedi...)copy SMILEScopy InChI
Affinity DataKi:  1.53E+7nM ΔG°:  -10.5kJ/molepH: 7.8 T: 2°CAssay Description:Enzyme reaction was monitored by measuring the NADH absorption at 340 nm on a UV-Vis spectrometer. The formation of NADH was measured for 30 s. Data ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87824PubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306131(1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of SCD1 in HEK293A cell microsomes assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306131(1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human SCD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50306131(1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50330378(5-Chloro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50296309(4-(ethylamino)-3-(2-hydroxyethoxy)-N-(5-(3-(triflu...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of stearoyl-CoA desaturase 1 in human microsome assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ58VWPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50330378(5-Chloro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of SCD1 in HEK293A cell microsomes assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50306131(1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306131(1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306116(CHEMBL594289 | N-(2-hydroxy-2-phenylethyl)-6-(spir...)copy SMILEScopy InChI
Affinity DataIC50: 0.0680nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50330379(5,8-Difluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of SCD1 in HEK293A cell microsomes assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296527(CHEMBL552269 | N-(5-(3,5-difluorobenzyl)thiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50306129(1'-(6-(3-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50330380(5-Methyl-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296528(CHEMBL557445 | N-(5-(4-fluoro-3-(trifluoromethyl)b...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50296295(CHEMBL552173 | N-(5-(3,5-bis(trifluoromethyl)benzy...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50330380(5-Methyl-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SCD1 in HEK293A cell microsomes assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50008612(CHEMBL154588 | Sodium; 3-(2-mercaptomethyl-3-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMAssay Description:In vitro inhibitory activity against enkephalinase enzyme from rat.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QZ28ZDPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50306126(CHEMBL605412 | N-(2-hydroxy-2-(pyridin-3-yl)ethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50296295(CHEMBL552173 | N-(5-(3,5-bis(trifluoromethyl)benzy...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of stearoyl-CoA desaturase 1 in human microsome assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ58VWPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50330381(5-Fluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of SCD1 in HEK293A cell microsomes assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296309(4-(ethylamino)-3-(2-hydroxyethoxy)-N-(5-(3-(triflu...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of stearoyl-CoA desaturase 1 in mouse microsome assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ58VWPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306126(CHEMBL605412 | N-(2-hydroxy-2-(pyridin-3-yl)ethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306112(CHEMBL595247 | N-(2-hydroxy-2-phenylethyl)-6-(4-hy...)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50330379(5,8-Difluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306114(CHEMBL594084 | N-(2-hydroxy-2-phenylethyl)-6-(3-hy...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50306124(6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296295(CHEMBL552173 | N-(5-(3,5-bis(trifluoromethyl)benzy...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50296528(CHEMBL557445 | N-(5-(4-fluoro-3-(trifluoromethyl)b...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296295(CHEMBL552173 | N-(5-(3,5-bis(trifluoromethyl)benzy...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of stearoyl-CoA desaturase 1 in mouse microsome assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ58VWPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50296305(3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-(5-(3-(t...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of stearoyl-CoA desaturase 1 in human microsome assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ58VWPubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50306110(CHEMBL607314 | N-(2-hydroxy-2-phenylethyl)-6-(4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9WBJPubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50296526(CHEMBL552126 | N-(5-(3,5-dichlorobenzyl)thiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836H1PubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50330381(5-Fluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human SCD1 expressed in HEK293A cells assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ37CNPubMed
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