Compile Data Set for Download or QSAR
Found 164 with Last Name = 'whitaker' and Initial = 't'
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset, Inc.

Curated by ChEMBL
LigandPNGBDBM50480722(CHEMBL373691)copy SMILEScopy InChI
Affinity DataKi:  310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N83Z9PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset, Inc.

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N83Z9PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 96nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 96nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50432235(CHEMBL2347323)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TDKPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50387086(CHEMBL2047191)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8FHPPubMed
TargetAdenosine deaminase(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50356463(CHEMBL1911841)copy SMILEScopy InChI
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of adenosine deaminase assessed as conversion of adenosine to inosineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0FWDPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50432236(CHEMBL2347159)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TDKPubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset, Inc.

Curated by ChEMBL
LigandPNGBDBM50484706(CHEMBL1950241)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82D5RPubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset, Inc.

Curated by ChEMBL
LigandPNGBDBM50484704(CHEMBL1950242)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82D5RPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50432234(CHEMBL2347328)copy SMILEScopy InChI
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TDKPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM294045(US10106571, Example 2 | US10106571, Example 23)copy SMILES
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ6873PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50432233(CHEMBL2347337)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TDKPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)copy SMILEScopy InChI
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TDKPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)copy SMILEScopy InChI
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8FHPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048WPPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50442864(CHEMBL2441773)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z3213VPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50326056((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazin...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z3213VPubMed
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