Compile Data Set for Download or QSAR
Found 249 with Last Name = 'woods' and Initial = 'ta'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataKi:  4.13E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398506((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)copy SMILEScopy InChI
Affinity DataIC50: 1.49nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398504((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)copy SMILES
Affinity DataIC50: 1.91nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142253(CHEMBL3758924)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142252(CHEMBL3758953)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142254(CHEMBL3759288)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398501((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 3.25nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398502((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)copy SMILEScopy InChI
Affinity DataIC50: 5.25nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398505((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.35nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM398503((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)copy SMILEScopy InChI
Affinity DataIC50: 5.43nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TF00QZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318008(2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...)copy SMILEScopy InChI
Affinity DataIC50: 6.25nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318009(2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 6.58nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318034(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.54nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318039(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 8.41nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318007(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 9.95nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142255(CHEMBL3758222)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318040(2-[4-[(4-Chloropyrimidin-2-yl)methyl]piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 10.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318008(2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...)copy SMILEScopy InChI
Affinity DataIC50: 10.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318036(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 10.8nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318009(2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 10.9nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318026(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)copy SMILEScopy InChI
Affinity DataIC50: 11.3nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318025(US9624218, Example 19 | US9624218, Example 34)copy SMILEScopy InChI
Affinity DataIC50: 11.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318010(2-[4-[(3-Hydroxy-2- pyridyl)methyl]piperazin-1- yl...)copy SMILEScopy InChI
Affinity DataIC50: 11.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318020(8-Methyl-2-[4-[(4- methylpyrimidin-2- yl)methyl]pi...)copy SMILEScopy InChI
Affinity DataIC50: 11.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318025(US9624218, Example 19 | US9624218, Example 34)copy SMILEScopy InChI
Affinity DataIC50: 11.8nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318030(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)copy SMILEScopy InChI
Affinity DataIC50: 12.2nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318019(2-[4-[(4-methoxypyrimidin-2-yl)methyl]piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 12.4nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318043(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)copy SMILEScopy InChI
Affinity DataIC50: 12.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318042(2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...)copy SMILEScopy InChI
Affinity DataIC50: 12.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318041(8-Methyl-2-[4-(pyrazin-2-ylmethyl)piperazin-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318007(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 13.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318028(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)copy SMILEScopy InChI
Affinity DataIC50: 14.1nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318039(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 14.3nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318040(2-[4-[(4-Chloropyrimidin-2-yl)methyl]piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 14.5nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318019(2-[4-[(4-methoxypyrimidin-2-yl)methyl]piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 14.9nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318030(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)copy SMILEScopy InChI
Affinity DataIC50: 15.2nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318038(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 15.9nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318021(8-Methyl-2-[4-[[5-trifluoromethyl)pyrimidin-2- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 16.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318007(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 17.5nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318043(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)copy SMILEScopy InChI
Affinity DataIC50: 17.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318034(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)copy SMILEScopy InChI
Affinity DataIC50: 17.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318028(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)copy SMILEScopy InChI
Affinity DataIC50: 18.4nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142252(CHEMBL3758953)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318007(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 19.1nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318044(US9624218, Example 45)copy SMILEScopy InChI
Affinity DataIC50: 19.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM318036(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 19.8nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112CZUS Patent
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