Compile Data Set for Download or QSAR
Found 82 with Last Name = 'edwards' and Initial = 'te'
LigandPNGBDBM50150119(CHEMBL3769414)copy SMILEScopy InChI
Affinity DataIC50: 0.0580nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM50059026(5'-Methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spi...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol |...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50237791(CHEMBL1628659 | SCH-51866)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289618(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM50237799(CHEMBL4069196)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289615(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289614(6-(4-Chlorobenzyl)-9-benzyl-8,9,10,11-tetrahydropy...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289615(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289614(6-(4-Chlorobenzyl)-9-benzyl-8,9,10,11-tetrahydropy...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50237799(CHEMBL4069196)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289618(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 980nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)copy SMILEScopy InChI
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125VV2PubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50164648(2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human DNA polymerase-betaMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Affinity towards human 5-hydroxytryptamine 3 serotonin receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50065785(2-Methyl-quinolin-8-ol | CHEMBL316892)copy SMILEScopy InChI
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125VV2PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of PDE2A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 9.20E+3nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
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