Compile Data Set for Download or QSAR
Found 201 with Last Name = 'reddy' and Initial = 'tj'
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19516((2S)-N-[(3S,5E)-6-(benzenesulfonyl)-4-oxo-1-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270029(2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-pro...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649476(US11891378, Example 6)copy SMILES
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649472(US11891378, Example 2)copy SMILES
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649480(US11891378, Example 10)copy SMILES
Affinity DataIC50: 3.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649479(US11891378, Example 9)copy SMILES
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649477(US11891378, Example 7)copy SMILES
Affinity DataIC50: 5.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649473(US11891378, Example 3)copy SMILES
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649475(US11891378, Example 5)copy SMILES
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19516((2S)-N-[(3S,5E)-6-(benzenesulfonyl)-4-oxo-1-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649471(US11891378, Example 1)copy SMILES
Affinity DataIC50: 8.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270041(4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-di...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19492((2R)-2-{[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroeth...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270041(4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-di...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649474(US11891378, Example 4)copy SMILES
Affinity DataIC50: 12.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPantothenate kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM649478(US11891378, Example 8)copy SMILES
Affinity DataIC50: 12.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270030(2-Amino-N-((S)-1-benzyl-3-diazo-2-oxo-propyl)-acet...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270041(4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-di...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetMyeloblastin(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetMyeloblastin(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetNeutrophil elastase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetNeutrophil elastase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19492((2R)-2-{[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroeth...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50139666(5-(4-Acetyl-phenyl)-3-(2,4-dimethyl-benzenesulfony...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PV6JSNPubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19492((2R)-2-{[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroeth...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270041(4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-di...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetCathepsin G(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270040((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50126676(2-[4-(4'-Chloro-4-methoxy-biphenyl-2-ylmethoxy)-ph...)copy SMILEScopy InChI
Affinity DataIC50: 620nMAssay Description:Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP74BPPubMed
TargetCathepsin G(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50126679((S)-2-(2,4-dichloro-N-(3-nitrobenzyl)benzamido)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP74BPPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50139669(3-(4-Chloro-2-methyl-benzenesulfonylamino)-5-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 750nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PV6JSNPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)copy SMILEScopy InChI
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269859(2,2,2-trifluoroacetate; 5-(2-azaniumyl-2-{[(1S,2S)...)copy SMILEScopy InChI
Affinity DataIC50: 790nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TJMPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50126666(2-[(3-Cyano-benzyl)-(2,4-dichloro-benzoyl)-amino]-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP74BPPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50139657(3-(2,4-Dimethyl-benzenesulfonylamino)-5-phenyl-thi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PV6JSNPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Shire BioChem Inc.

Curated by ChEMBL
LigandPNGBDBM50139657(3-(2,4-Dimethyl-benzenesulfonylamino)-5-phenyl-thi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K35T2NPubMed
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