Compile Data Set for Download or QSAR
Found 217 with Last Name = 'nechuta' and Initial = 'tl'
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039513((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039499((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039541((S)-2-((S)-2-Mercaptomethyl-3-naphthalen-1-yl-prop...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039530((S)-3-Ethylsulfanyl-2-((S)-2-mercaptomethyl-3-phen...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039537((R)-2-(2-Mercaptomethyl-pentanoylamino)-4-methylsu...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039508((S)-3-Benzylsulfanyl-2-[(S)-3-(4-chloro-phenyl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476438(CHEMBL233298)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039509((R)-2-[(1-Mercaptomethyl-cyclopentanecarbonyl)-ami...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039515((R)-2-((R)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476450(CHEMBL233724)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039538((R)-2-(2-Mercaptomethyl-3-phenyl-propionylamino)-4...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322938(2-(3-chloro-4-fluorophenyl)-N-(3,5-difluorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322938(2-(3-chloro-4-fluorophenyl)-N-(3,5-difluorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039516((R)-4-Ethylsulfanyl-2-((S)-2-mercaptomethyl-3-phen...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039504((S)-3-Ethylsulfanyl-2-(2-mercaptomethyl-3-phenyl-p...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039523((R)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039529((R)-2-((S)-2-Mercaptomethyl-3-o-tolyl-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476437(CHEMBL398137)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476443(CHEMBL392993)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476456(CHEMBL233928)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476452(CHEMBL391522)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039514((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016767(2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Compound was evaluated for the ability to inhibit Angiotensin I converting enzyme in ratMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016767(2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidneyMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016766(2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidneyMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476438(CHEMBL233298)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476449(CHEMBL393414)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039524((S)-3-Benzylsulfanyl-2-((S)-2-mercaptomethyl-3-phe...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016769(2-[1-(2-Carboxy-ethylcarbamoyl)-2-phenyl-ethylamin...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidneyMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50196898(((2R,6S)-1-(4-chlorophenylsulfonyl)-6-phenylpiperi...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476439(CHEMBL232887)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322940(2-(3,4-difluorophenyl)-1-oxo-3-(pyridin-2-yl)-N-(3...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039500((S)-2-((R)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Ttested for its inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322940(2-(3,4-difluorophenyl)-1-oxo-3-(pyridin-2-yl)-N-(3...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322943(2-(3-chlorophenyl)-N-(3,5-difluorophenyl)-1-oxo-3-...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322943(2-(3-chlorophenyl)-N-(3,5-difluorophenyl)-1-oxo-3-...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039540((R)-3-Benzylsulfanyl-2-((S)-2-mercaptomethyl-3-phe...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039514((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Tested in vitro for its inhibitory activity against angiotensin converting enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016765(2-[1-(2-Carboxy-ethylcarbamoyl)-2-phenyl-ethylamin...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidneyMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039531((S)-2-((R)-2-Mercaptomethyl-3-phenyl-propionylamin...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50016768(2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidneyMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7FMFPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476440(CHEMBL233097)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476444(CHEMBL392587)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476454(CHEMBL233505)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039530((S)-3-Ethylsulfanyl-2-((S)-2-mercaptomethyl-3-phen...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Tested in vitro for its inhibitory activity against angiotensin converting enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322950(2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluo...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50322950(2-(3-chloro-4-fluorophenyl)-7-(5-fluoro-6-(trifluo...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V34PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039525((R)-4-Ethylsulfanyl-2-((R)-2-mercaptomethyl-3-phen...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50039510((S)-3-Benzylsulfanyl-2-((R)-2-mercaptomethyl-3-phe...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B20PubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476447(CHEMBL232495)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP48WPPubMed
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