Compile Data Set for Download or QSAR
Found 154 with Last Name = 'macdonald' and Initial = 'tt'
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)copy SMILEScopy InChI
Affinity DataIC50: 0.0630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)copy SMILEScopy InChI
Affinity DataIC50: 0.0790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233244(CHEMBL4068954)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233248(CHEMBL4096224)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233255(CHEMBL4069318)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis at 21 hrs post-st...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233228(CHEMBL4060644)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233230(CHEMBL4099004)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233226(CHEMBL4089558)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-MIP-1beta production at 21 hrs post-s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233249(CHEMBL4081685)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233229(CHEMBL4088857)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159508(CHEMBL3786078)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233250(CHEMBL4099698)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233252(CHEMBL4080978)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis by measuring cell...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233241(CHEMBL4071080)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50184765(CHEMBL3823499)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of rat RIPK2 preincubated for 10 mins followed by addition of fluorescent-labeled 2-Methyl-5-(2-propen-l-yloxy)aniline measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length FLAG/His-tagged RIP2 measured after 2 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of fluorescent-labelled ligand binding to rat RIP2K preincubated for 10 mins followed by fluorescent-labelled ligand addition and measured...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human whole blood assessed as reduction in TNFalpha/QCD-OPh/zVAD FMK/SMAC mimetic RMT 5265-MIP-1beta production after 6 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM25198(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM25198(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233226(CHEMBL4089558)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50516676(CHEMBL4473105)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of fluorescent-labelled ligand binding to human RIP2K preincubated for 10 mins followed by fluorescent-labelled ligand addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XKFPubMed
TargetNucleotide-binding oligomerization domain-containing protein 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced IL8 production measured after 22 hrs by HTRF fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XKFPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233242(CHEMBL4069959)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233230(CHEMBL4099004)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of fluorescent-labelled ligand binding to human RIP2K preincubated for 10 mins followed by fluorescent-labelled ligand addition and measur...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50184765(CHEMBL3823499)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50184479(CHEMBL3822791)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233250(CHEMBL4099698)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233255(CHEMBL4069318)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233229(CHEMBL4088857)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233244(CHEMBL4068954)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50184727(CHEMBL3822938)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50184764(CHEMBL3822577)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233228(CHEMBL4060644)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G162SQPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233248(CHEMBL4096224)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92NRPubMed
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