Compile Data Set for Download or QSAR
Found 411 with Last Name = 'magee' and Initial = 'tv'
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)copy SMILEScopy InChI
Affinity DataKi:  4.5nMAssay Description:Mixed noncompetitive inhibition of recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC074MPubMed
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of 1 nM recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC074MPubMed
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILES
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319605(US10174007, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM464138(US10787438, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319602(US10174007, Example 42 | US10787438, Example 42 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494882(US10988463, Example 42 | [(1R,5S,6R)-3-{5-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319602(US10174007, Example 42 | US10787438, Example 42 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319602(US10174007, Example 42 | US10787438, Example 42 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319605(US10174007, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:A third KHK assay, referred to as Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM464138(US10787438, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILES
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319600(US10174007, Example 24 | US10787438, Example 24 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319600(US10174007, Example 24 | US10787438, Example 24 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:A third KHK assay, referred to as Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319600(US10174007, Example 24 | US10787438, Example 24 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494880(US10988463, Example 24 | [(1R,5S,6R)-3-{2-[(2S,3R)...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:A third KHK assay, referred to as Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494881(US10988463, Example 40 | [(1R,5S,6R)-3-{5-chloro-6...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319601(US10174007, Example 40 | US10787438, Example 40 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319601(US10174007, Example 40 | US10787438, Example 40 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319601(US10174007, Example 40 | US10787438, Example 40 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILES
Affinity DataIC50: 4.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILES
Affinity DataIC50: 4.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B2807K
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM319605(US10174007, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20867DXUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM464138(US10787438, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ35RPUS Patent
TargetKetohexokinase(Homo sapiens (Human))TBA
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PRSUS Patent
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195581((2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinop...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer Inc.

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X56K5PubMed
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