Compile Data Set for Download or QSAR
Found 431 with Last Name = 'nguyen-tran' and Initial = 'v'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22158((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nM EC50:  1.40nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22160(pyrazole compound, 14a | sodium 5-({5-[(1E,3S,5R)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nM EC50:  13.7nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22157((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-methyl-1H-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nM EC50:  1.5nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22163(BMS-644950 | sodium (3R,5S,6E)-7-[4-(4-fluoropheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nM EC50:  3.95nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22154((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-methyl-1H-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nM EC50:  3.70nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279275(CHEMBL4176853)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22152((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[N-(1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nM EC50:  5.40nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22147((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(1,2-oxazol-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nM EC50:  1.40nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22150((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-methyl-1H-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nM EC50:  1.30nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22155((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nM EC50:  1.20nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22151((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nM EC50:  2.5nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22162(sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[N-(1-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nM EC50:  7.5nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279291(CHEMBL4171924)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279292(CHEMBL4161327)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22161(sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 3nM EC50:  3.70nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538098(CHEMBL4640031)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nM EC50:  0.600nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22156((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[N-(1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nM EC50:  7.70nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22159((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[N-(1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nM EC50:  1nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM18375((3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutan...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nM EC50:  6.20nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279311(CHEMBL4160817)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279297(CHEMBL4173493)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279302(CHEMBL4161723)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279317(CHEMBL4166239)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538084(CHEMBL4647659)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human DYRK1A (129 to 509 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Mus musculus)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279297(CHEMBL4173493)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of RIPK2 in C57BL/6 mouse BMDM assessed as reduction in MDP/LPS-stimulated IL6 secretion pretreated for 30 mins followed by MDP/LPS stimul...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22164((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylca...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nM EC50:  2.5nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538099(CHEMBL4636064)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22146((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(5-phenyl-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nM EC50:  7.70nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279303(CHEMBL4170048)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22148((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(1,2-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 7nM EC50:  9nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279325(CHEMBL4159424)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279296(CHEMBL4162788)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279317(CHEMBL4166239)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of RIPK2 in human PBMCs assessed as reduction in MDP-stimulated IL8 secretion measured after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279275(CHEMBL4176853)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of RIPK2 in human PBMCs assessed as reduction in MDP-stimulated IL8 secretion measured after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279313(CHEMBL4164217)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 9.80nM EC50:  2.30nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279323(CHEMBL4168738)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Mus musculus)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279292(CHEMBL4161327)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of RIPK2 in C57BL/6 mouse BMDM assessed as reduction in MDP/LPS-stimulated IL6 secretion pretreated for 30 mins followed by MDP/LPS stimul...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538095(CHEMBL4649473)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb Company

LigandPNGBDBM22153((3R,5S,6E)-7-{2-[(3-tert-butyl-1-methyl-1H-pyrazol...)copy SMILEScopy InChI
Affinity DataIC50: 12.4nM EC50:  1.90nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8JB2PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538090(CHEMBL4648742)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538093(CHEMBL4645474)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538084(CHEMBL4647659)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GSK3beta (1 to 433 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279320(CHEMBL4163484)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538091(CHEMBL4640465)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50538094(CHEMBL4641631)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ079VPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279316(CHEMBL4167668)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279290(CHEMBL4171039)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50279293(CHEMBL4162913)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SBPPubMed
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