Compile Data Set for Download or QSAR
Found 1780 with Last Name = 'palombella' and Initial = 'v'
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mus musculus (Mouse))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 incubated for 30 mins followed by...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50293788(CHEMBL538867 | N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant SMO expressed in mouse C3H10T1/2 cells assessed as inhibition of association of BODIPY-cyclopamineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC10QMPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192889(CHEMBL3975359)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192882(CHEMBL3937119)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192899(CHEMBL3963736)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192883(CHEMBL3976330)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192901(CHEMBL3911278)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192885(CHEMBL3923629 | US10329299, Compound 54 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130245(6,8-Dichloro-7-cyclopropylmethoxy-9H-beta-carbolin...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130248(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192881(CHEMBL3914602 | US10329299, Compound 30 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192888(CHEMBL3947903)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192895(CHEMBL3928146 | US10329299, Compound 17 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130221(6,8-Dichloro-7-ethoxy-9H-beta-carboline | CHEMBL81...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
LigandPNGBDBM50192892(CHEMBL3966879 | US10329299, Compound 5 | US1067528...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192891(CHEMBL3959293)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130224(6,8-Dichloro-7-methoxy-9H-beta-carboline | CHEMBL3...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192894(CHEMBL3893430 | US10329299, Compound 32 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of PI3Kdelta in IgM-stimulated human Raji cells assessed as reduction in AKT phosphorylation at S473 incubated for 30 mins followed by sti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130238(6,8-Dichloro-9H-beta-carboline | CHEMBL78464)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in AKT phosphorylation at S473 after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192897(CHEMBL3944056)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192880(CHEMBL3984425 | US10329299, Compound 21 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of PI3Kalpha in human SKOV-3 cells assessed as reduction in AKT phosphorylation at S473 after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192892(CHEMBL3966879 | US10329299, Compound 5 | US1067528...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130246(CHEMBL80843 | N-(6-Chloro-9H-beta-carbolin-8-yl)-i...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192900(CHEMBL3917188 | US10919914, Compound 31)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192901(CHEMBL3911278)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192886(CHEMBL3946030 | US10329299, Compound 70 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192911(CHEMBL3955769 | US10329299, Compound 26 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192908(CHEMBL3895629 | US10329299, Compound 59 | US106752...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192890(CHEMBL3908224)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192899(CHEMBL3963736)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192883(CHEMBL3976330)copy SMILEScopy InChI
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192891(CHEMBL3959293)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130235(6-Bromo-9H-beta-carboline | CHEMBL81169)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130247(6-Chloro-9H-beta-carboline | CHEMBL311201)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130243(CHEMBL80121 | N-(6-Chloro-9H-beta-carbolin-8-yl)-a...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130225(CHEMBL310179 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130230(CHEMBL78862 | N-(6-Chloro-9H-beta-carbolin-8-yl)-b...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130222((6-Chloro-9H-beta-carbolin-8-yl)-carbamic acid met...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
LigandPNGBDBM50192889(CHEMBL3975359)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192890(CHEMBL3908224)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192884(CHEMBL3978650)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192896(CHEMBL3916095)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
LigandPNGBDBM50192882(CHEMBL3937119)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130233(5-Bromo-6-methoxy-9H-beta-carboline | CHEMBL310975)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50130223(CHEMBL78917 | Pyridine-2-carboxylic acid (6-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0FJ7PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192884(CHEMBL3978650)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018HXPubMed
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