Compile Data Set for Download or QSAR
Found 93 with Last Name = 'kaushik' and Initial = 'vk'
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572983(CHEMBL4848846)copy SMILES
Affinity DataKi:  2.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572968(CHEMBL4862851)copy SMILES
Affinity DataKi:  8.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572964(CHEMBL4867592)copy SMILES
Affinity DataKi:  1.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572989(CHEMBL4846332)copy SMILES
Affinity DataKi:  3.60E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572991(CHEMBL4858967)copy SMILES
Affinity DataKi:  4.20E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572990(CHEMBL4859105)copy SMILES
Affinity DataKi:  4.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572988(CHEMBL4855695)copy SMILES
Affinity DataKi:  5.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50572984(CHEMBL4874198)copy SMILES
Affinity DataKi:  7.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21489((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.440nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [166-489](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21488((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21486((2S)-2-{[(1S)-1-carboxy-2-{1-[(3-methylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
TargetSerine/threonine-protein kinase WNK1 [1-434](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
TargetSerine/threonine-protein kinase WNK1 [1-444](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21487((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,4-dimethylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21491((2S)-2-{[(1S)-1-carboxy-2-[1-(2-cyclohexylpropan-2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21482((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-chlorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21484((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-methylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 32nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 41nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21483((2S)-2-{[(1S)-1-carboxy-2-(1-{[4-(trifluoromethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 52nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21481((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-nitrophenyl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 76nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50013867(CHEMBL3265299)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17VPPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21480((2S)-2-{[(1S)-1-carboxy-2-[1-(cyclohexylmethyl)-1H...)copy SMILEScopy InChI
Affinity DataIC50: 270nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21485((2S)-2-{[(1S)-1-carboxy-2-{1-[(2-methylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 290nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
LigandPNGBDBM50572983(CHEMBL4848846)copy SMILES
Affinity DataIC50: 300nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21478((2S)-2-{[(1S)-2-(1-benzyl-1H-imidazol-5-yl)-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Millennium Pharmaceuticals

LigandPNGBDBM21479((2S)-2-{[(1S)-2-(1-benzyl-1H-imidazol-5-yl)-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 340nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
LigandPNGBDBM50572986(CHEMBL4878031)copy SMILES
Affinity DataIC50: 370nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203826((R)-1-(1-(2-(4-methoxyphenyl)acetyl)pyrrolidin-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 856nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FH5PubMed
LigandPNGBDBM50572968(CHEMBL4862851)copy SMILES
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572970(CHEMBL4876393)copy SMILES
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572976(CHEMBL4848878)copy SMILES
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
Millennium Pharmaceuticals

LigandPNGBDBM21478((2S)-2-{[(1S)-2-(1-benzyl-1H-imidazol-5-yl)-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMpH: 7.5 T: 2°CAssay Description:Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
LigandPNGBDBM50572964(CHEMBL4867592)copy SMILES
Affinity DataIC50: 4.00E+3nMAssay Description:Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50041687(CHEMBL3358899)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+3nMAssay Description:Binding affinity to human MCL1 (173 to 329 aa) using TAMRA-labeled Noxa peptide preincubated for 30 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17VPPubMed
LigandPNGBDBM50572974(CHEMBL4853507)copy SMILES
Affinity DataIC50: 4.20E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50041679(CHEMBL3358892)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:Binding affinity to human MCL1 (173 to 329 aa) using TAMRA-labeled Noxa peptide preincubated for 30 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50572978(CHEMBL4877617)copy SMILES
Affinity DataIC50: 4.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572969(CHEMBL4867285)copy SMILES
Affinity DataIC50: 4.60E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572965(CHEMBL4875218)copy SMILES
Affinity DataIC50: 5.40E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572975(CHEMBL4867497)copy SMILES
Affinity DataIC50: 6.10E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
LigandPNGBDBM50572990(CHEMBL4859105)copy SMILES
Affinity DataIC50: 7.50E+3nMAssay Description:Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977DHPubMed
TargetAngiotensin-converting enzyme(Sus scrofa (pig))
Millennium Pharmaceuticals

LigandPNGBDBM21488((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
Millennium Pharmaceuticals

LigandPNGBDBM21488((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme(Sus scrofa (pig))
Millennium Pharmaceuticals

LigandPNGBDBM21491((2S)-2-{[(1S)-1-carboxy-2-[1-(2-cyclohexylpropan-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50041674(CHEMBL3358901)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human MCL1 (173 to 329 aa) using TAMRA-labeled Noxa peptide preincubated for 30 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17VPPubMed
TargetAngiotensin-converting enzyme(Sus scrofa (pig))
Millennium Pharmaceuticals

LigandPNGBDBM21487((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,4-dimethylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme(Sus scrofa (pig))
Millennium Pharmaceuticals

LigandPNGBDBM21484((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-methylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
TargetAngiotensin-converting enzyme(Sus scrofa (pig))
Millennium Pharmaceuticals

LigandPNGBDBM21486((2S)-2-{[(1S)-1-carboxy-2-{1-[(3-methylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP80FNPubMed
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