Compile Data Set for Download or QSAR
Found 59 with Last Name = 'moretti' and Initial = 'w'
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31541(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31542(pyrazolo[4,3-h]quinazoline-3-carboxamide, 25)copy SMILEScopy InChI
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31544(pyrazolo[4,3-h]quinazoline-3-carboxamide, 27)copy SMILEScopy InChI
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31533(pyrazolo[4,3-h]quinazoline-3-carboxamide, 16)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31543(pyrazolo[4,3-h]quinazoline-3-carboxamide, 26)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31549(pyrazolo[4,3-h]quinazoline-3-carboxamide, 32)copy SMILEScopy InChI
Affinity DataIC50: 29nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31541(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)copy SMILEScopy InChI
Affinity DataIC50: 30nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31546(pyrazolo[4,3-h]quinazoline-3-carboxamide, 29)copy SMILEScopy InChI
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31557(pyrazolo[4,3-h]quinazoline-3-carboxamide, 40)copy SMILEScopy InChI
Affinity DataIC50: 35nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31553(pyrazolo[4,3-h]quinazoline-3-carboxamide, 36)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31540(pyrazolo[4,3-h]quinazoline-3-carboxamide, 23)copy SMILEScopy InChI
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31550(pyrazolo[4,3-h]quinazoline-3-carboxamide, 33)copy SMILEScopy InChI
Affinity DataIC50: 47nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)copy SMILEScopy InChI
Affinity DataIC50: 50nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31542(pyrazolo[4,3-h]quinazoline-3-carboxamide, 25)copy SMILEScopy InChI
Affinity DataIC50: 51nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 53nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)copy SMILEScopy InChI
Affinity DataIC50: 53nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31551(pyrazolo[4,3-h]quinazoline-3-carboxamide, 34)copy SMILEScopy InChI
Affinity DataIC50: 55nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31552(pyrazolo[4,3-h]quinazoline-3-carboxamide, 35)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31555(pyrazolo[4,3-h]quinazoline-3-carboxamide, 38)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31535(pyrazolo[4,3-h]quinazoline-3-carboxamide, 18)copy SMILEScopy InChI
Affinity DataIC50: 74nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31534(pyrazolo[4,3-h]quinazoline-3-carboxamide, 17)copy SMILEScopy InChI
Affinity DataIC50: 81nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31558(pyrazolo[4,3-h]quinazoline-3-carboxamide, 41)copy SMILEScopy InChI
Affinity DataIC50: 83nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31547(pyrazolo[4,3-h]quinazoline-3-carboxamide, 30)copy SMILEScopy InChI
Affinity DataIC50: 137nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31554(pyrazolo[4,3-h]quinazoline-3-carboxamide, 37)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31540(pyrazolo[4,3-h]quinazoline-3-carboxamide, 23)copy SMILEScopy InChI
Affinity DataIC50: 175nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31534(pyrazolo[4,3-h]quinazoline-3-carboxamide, 17)copy SMILEScopy InChI
Affinity DataIC50: 213nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31556(pyrazolo[4,3-h]quinazoline-3-carboxamide, 39)copy SMILEScopy InChI
Affinity DataIC50: 220nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31548(pyrazolo[4,3-h]quinazoline-3-carboxamide, 31)copy SMILEScopy InChI
Affinity DataIC50: 248nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 265nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31533(pyrazolo[4,3-h]quinazoline-3-carboxamide, 16)copy SMILEScopy InChI
Affinity DataIC50: 312nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 363nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31535(pyrazolo[4,3-h]quinazoline-3-carboxamide, 18)copy SMILEScopy InChI
Affinity DataIC50: 364nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31538(pyrazolo[4,3-h]quinazoline-3-carboxamide, 21)copy SMILEScopy InChI
Affinity DataIC50: 374nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 398nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31553(pyrazolo[4,3-h]quinazoline-3-carboxamide, 36)copy SMILEScopy InChI
Affinity DataIC50: 535nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)copy SMILEScopy InChI
Affinity DataIC50: 574nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31544(pyrazolo[4,3-h]quinazoline-3-carboxamide, 27)copy SMILEScopy InChI
Affinity DataIC50: 582nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31548(pyrazolo[4,3-h]quinazoline-3-carboxamide, 31)copy SMILEScopy InChI
Affinity DataIC50: 625nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31554(pyrazolo[4,3-h]quinazoline-3-carboxamide, 37)copy SMILEScopy InChI
Affinity DataIC50: 638nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31547(pyrazolo[4,3-h]quinazoline-3-carboxamide, 30)copy SMILEScopy InChI
Affinity DataIC50: 649nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31555(pyrazolo[4,3-h]quinazoline-3-carboxamide, 38)copy SMILEScopy InChI
Affinity DataIC50: 855nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31546(pyrazolo[4,3-h]quinazoline-3-carboxamide, 29)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+3nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31538(pyrazolo[4,3-h]quinazoline-3-carboxamide, 21)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+3nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31552(pyrazolo[4,3-h]quinazoline-3-carboxamide, 35)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+3nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences Srl

LigandPNGBDBM31549(pyrazolo[4,3-h]quinazoline-3-carboxamide, 32)copy SMILEScopy InChI
Affinity DataIC50: 1.34E+3nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3JJPPubMed
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