Affinity DataIC50: 1nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 25.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 26.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 31.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Pfizer St. Louis Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair