Compile Data Set for Download or QSAR
Found 213 with Last Name = 'naing' and Initial = 'w'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347099(CHEMBL1797202)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347100(CHEMBL1797203)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347929(CHEMBL1802632)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347096(CHEMBL1797123)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347106(CHEMBL1797209)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347938(CHEMBL1802637)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347126(CHEMBL1797124)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347937(CHEMBL1802641)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347107(CHEMBL1797210)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347098(CHEMBL1797201)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347109(CHEMBL1797212)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347105(CHEMBL1797208)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318014(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347103(CHEMBL1797206)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347108(CHEMBL1797211)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347110(CHEMBL1797213)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347933(CHEMBL1802636)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347111(CHEMBL1797214)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347930(CHEMBL1802633)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347121(CHEMBL1797224)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347121(CHEMBL1797224)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315107(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347101(CHEMBL1797204)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347104(CHEMBL1797207)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347116(CHEMBL1797219)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318015(2-chloro-5-(5-fluoropyrimidin-2-yl)-N-((1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318009(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-(hy...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318018(2-chloro-N-((2-fluoro-1-hydroxycycloheptyl)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347123(CHEMBL1797226)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318012(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(6-met...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315120((1S,2S)-2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347114(CHEMBL1797217)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347934(CHEMBL1802638)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318013(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50310966(4-((3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-o...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59DGPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347102(CHEMBL1797205)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50310971(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(4-(2...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM59DGPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315129(4-(3-(4-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 25.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315134(4-(5-(1-methylpiperidin-4-yl)-3-(3-(trifluoromethy...)copy SMILEScopy InChI
Affinity DataIC50: 26.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318021(2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347097(CHEMBL1797125)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4WFHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315118(4-(3-(4-chlorophenyl)-5-(1-(tetrahydrofuran-3-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50315131(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 31.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N818HPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318010(2-chloro-5-(5-fluoropyridin-2-yl)-N-((1-hydroxycyc...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318016(2-chloro-5-(5-fluoropyrimidin-2-yl)-N-((1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Pfizer St. Louis Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318005(2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50N4QPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50347931(CHEMBL1802634)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46R2PubMed
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