Compile Data Set for Download or QSAR
Found 436 with Last Name = 'seghezzi' and Initial = 'w'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332163((S)-2-(4-(dimethylcarbamoyl)phenyl)-4-(piperidin-3...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332159((S)-2-(4-carbamoylphenyl)-4-(piperidin-3-ylamino)t...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332171((S)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thie...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332131((S)-2-(3-acetamidophenyl)-4-(piperidin-3-ylamino)t...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433481(CHEMBL2381115)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332134((S)-2-(3,4-difluorophenyl)-4-(piperidin-3-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332150((S)-2-(4-(methylsulfonyl)phenyl)-4-(piperidin-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332172(5-(4-chlorophenyl)-N-cyclohexyl-2-ureidothiophene-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332132((S)-2-(3-aminophenyl)-4-(piperidin-3-ylamino)thien...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332156((S)-2-(benzofuran-2-yl)-4-(piperidin-3-ylamino)thi...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433490(CHEMBL2381246)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433488(CHEMBL2381249)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332162((S)-4-(piperidin-3-ylamino)-2-(3-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332177((S)-4-(azepan-3-ylamino)-2-(4-chlorophenyl)thieno[...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334854(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334855(6-iodo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433486(CHEMBL2381102)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433483(CHEMBL2381112)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433480(CHEMBL2381221)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433479(CHEMBL2381222)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332133((S)-4-(piperidin-3-ylamino)-2-(pyridin-4-yl)thieno...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334853(6-chloro-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332173((S)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thie...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332141((S)-2-(4-methoxyphenyl)-4-(piperidin-3-ylamino)thi...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332142((S)-2-(3-(hydroxymethyl)phenyl)-4-(piperidin-3-yla...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332140((S)-2-(3-methoxyphenyl)-4-(piperidin-3-ylamino)thi...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332164((S)-2-(6-methoxypyridin-3-yl)-4-(piperidin-3-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433476(CHEMBL2381116)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332144((S)-2-(4-phenoxyphenyl)-4-(piperidin-3-ylamino)thi...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332143((S)-2-(benzo[b]thiophen-5-yl)-4-(piperidin-3-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332136((S)-2-phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]p...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332155((S)-2-(3-chloro-4-fluorophenyl)-4-(piperidin-3-yla...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433478(CHEMBL2381223)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332130((S)-2-(3-chlorophenyl)-4-(piperidin-3-ylamino)thie...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334849(CHEMBL1643236 | Syn-5-((3-aminocyclohexyl)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433489(CHEMBL2381248)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332152((S)-2-(4-fluorophenyl)-4-(piperidin-3-ylamino)thie...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332135((S)-4-(piperidin-3-ylamino)-2-(pyridin-3-yl)thieno...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332160((S)-4-(piperidin-3-ylamino)-2-(quinolin-6-yl)thien...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332138((S)-2-(1H-indol-4-yl)-4-(piperidin-3-ylamino)thien...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332129((S)-2-(3,5-difluorophenyl)-4-(piperidin-3-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332149((S)-4-(piperidin-3-ylamino)-2-(4-(trifluoromethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334876(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(thiomorpho...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334847(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433484(CHEMBL2381111)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334848(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZC9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332121(2-(4-chlorophenyl)-4-(2-(methylamino)ethylamino)th...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332151((S)-2-(3-cyanophenyl)-4-(piperidin-3-ylamino)thien...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50433482(CHEMBL2381114)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V19PubMed
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