Compile Data Set for Download or QSAR
Found 283 with Last Name = 'stark' and Initial = 'w'
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33970(maleimide derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33970(maleimide derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391897(CHEMBL2147537)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391902(CHEMBL2147542)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)copy SMILEScopy InChI
Affinity DataIC50: 4nM EC50:  3.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33970(maleimide derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391897(CHEMBL2147537)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 6.60nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391902(CHEMBL2147542)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33969(maleimide derivative, 11)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33970(maleimide derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391903(CHEMBL2147543)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM50391897(CHEMBL2147537)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391904(CHEMBL2147544)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33968(maleimide derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391903(CHEMBL2147543)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391904(CHEMBL2147544)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)copy SMILEScopy InChI
Affinity DataIC50: 13nM EC50:  24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PQQPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391911(CHEMBL2147551)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33967(maleimide derivative, 9)copy SMILEScopy InChI
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)copy SMILEScopy InChI
Affinity DataIC50: 17nM EC50:  10.3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50391910(CHEMBL2147550)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)copy SMILEScopy InChI
Affinity DataIC50: 19nM EC50:  16.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33970(maleimide derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 19nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM50324316(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6CZ4PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)copy SMILEScopy InChI
Affinity DataIC50: 21nM EC50:  32nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20585(2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1...)copy SMILEScopy InChI
Affinity DataIC50: 21nM EC50:  10.7nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PQQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)copy SMILEScopy InChI
Affinity DataIC50: 22nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
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