Compile Data Set for Download or QSAR
Found 29 with Last Name = 'friebe' and Initial = 'wg'
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11823(Azepane Derivative 4 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11823(Azepane Derivative 4 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11822((3R,4R)-3-(isonicotinoylamino)azepan-4-yl 4-(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11822((3R,4R)-3-(isonicotinoylamino)azepan-4-yl 4-(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11819((3R,4R)-N-{4-[4-(2-hydroxy-5-piperidin-1-ylbenzoyl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1V3SPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11820((3R,4R)-N-(4-{4-[5-(3,3-dimethylpiperidin-1-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1V3SPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11817((3R,4R)-N-{4-[4-(5-dimethylamino-2-hydroxybenzoyl)...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1V3SPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM1368(9b-(3-methylphenyl)-2H,3H,5H,9bH-isoindolo[1,2-b][...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11817((3R,4R)-N-{4-[4-(5-dimethylamino-2-hydroxybenzoyl)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11824(Azepane Derivative 5 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11821((3R,4R)-N-(4-{4-[5-(4,4-dimethylpiperidin-1-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1V3SPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM1361(9b-(naphthalen-1-yl)-2H,3H,5H,9bH-isoindolo[1,2-b]...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6R9JPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM50010223((S)-7-Allyl-8-methyl-6,7,8,9-tetrahydro-2H-2,7,9a-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6R9JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11827(Azepane Derivative 8 | N-((3S,4S)-4-{(E)-2-[4-(2-f...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM1354(9-Phenyl-2,3-Dihydrothiazola[2,3-a]isoindol-5(9bH)...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6R9JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11824(Azepane Derivative 5 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 355nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11827(Azepane Derivative 8 | N-((3S,4S)-4-{(E)-2-[4-(2-f...)copy SMILEScopy InChI
Affinity DataIC50: 360nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11819((3R,4R)-N-{4-[4-(2-hydroxy-5-piperidin-1-ylbenzoyl...)copy SMILEScopy InChI
Affinity DataIC50: 400nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11818((3R,4R)-N-(4-{4-[3-(3,3-dimethylpiperidin-2-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 750nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1V3SPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11826(Azepane Derivative 7 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM50033579(16-thia-9-azatetracyclo[7.6.3.02,7.010,15]octadeca...)copy SMILEScopy InChI
Affinity DataIC50: 830nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6R9JPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11821((3R,4R)-N-(4-{4-[5-(4,4-dimethylpiperidin-1-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11820((3R,4R)-N-(4-{4-[5-(3,3-dimethylpiperidin-1-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11818((3R,4R)-N-(4-{4-[3-(3,3-dimethylpiperidin-2-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11826(Azepane Derivative 7 | N-((3R,4R)-4-{[4-(2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim GmbH

Curated by ChEMBL
LigandPNGBDBM50033578(9b-Phenyl-2,3-dihydro-9bH-thiazolo[2,3-a]isoindol-...)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+3nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6R9JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Roche Diagnostics GmbH

LigandPNGBDBM11825(Azepane Derivative 6 | N-[(3S,4S)-4-({[4-(2-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMpH: 7.5 T: 2°CAssay Description:An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Diagnostics GmbH

LigandPNGBDBM11825(Azepane Derivative 6 | N-[(3S,4S)-4-({[4-(2-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+4nMpH: 7.2 T: 2°CAssay Description:In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1BNXPubMed