Compile Data Set for Download or QSAR
Found 164 with Last Name = 'kerr' and Initial = 'wj'
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataKi:  0.0398nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519160(CHEMBL4468357)copy SMILEScopy InChI
Affinity DataKi:  0.107nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519162(CHEMBL4573716)copy SMILEScopy InChI
Affinity DataKi:  0.174nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of integrin alphavbeta1 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)copy SMILEScopy InChI
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)copy SMILEScopy InChI
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)copy SMILEScopy InChI
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD3 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ligand binding to integrin alphavbeta8 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ligand binding to integrin alphavbeta1 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ligand binding to integrin alphavbeta6 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human fibronectin binding to human integrin alphavbeta1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464100(CHEMBL4243367)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of ligand binding to integrin alphavbeta5 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464113(CHEMBL4239085)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519162(CHEMBL4573716)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519160(CHEMBL4468357)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of ligand binding to integrin alphavbeta3 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50062938(CHEMBL3397909 | N-[(3S)-1-Acryloyl-3-pyrrolidinyl]...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandPNGBDBM50463770(CHEMBL4238919)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73HD3PubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213220(N-[(3S)-1-Acryloyl-3-pyrrolidinyl]-4-{[cis-2,6-dim...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213221((S)-1-(3-((4-(Piperidin-1-ylmethyl)-6-(thiazolo[5,...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519163(CHEMBL4593110)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213223(1-((S)-3-((4-((((R)-3,3-Dimethylbutan-2-yl)amino)m...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464100(CHEMBL4243367)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandPNGBDBM50463771(CHEMBL4250651)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73HD3PubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464113(CHEMBL4239085)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to LAP-bi by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519164(CHEMBL4446786)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519159(CHEMBL4589933)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213219((S)-1-(3-((4-(Morpholinomethyl)-6-(thiazolo[5,4-b]...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73HD3PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464113(CHEMBL4239085)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to human vitronectin incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Antagonist activity at integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to LAP-b by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75KQHPubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandPNGBDBM50463770(CHEMBL4238919)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase ATPase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73HD3PubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213222((S)-1-(3-((4-((Dimethylamino)methyl)-6-(thiazolo[5...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
GSK

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q0NPubMed
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