Compile Data Set for Download or QSAR
Found 19 with Last Name = 'marechal' and Initial = 'x'
TargetNeprilysin(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005638(CHEMBL3235414)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005640(CHEMBL3235415)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005637(CHEMBL3235413)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005636(CHEMBL3235412)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (1 to 40) hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer a...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant ECE1-mediated amyloid beta hydrolysis after 45 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005643(CHEMBL3235417)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant ACE2-mediated amyloid beta hydrolysis using Mca-Tyr-Val-Ala-Asp-Pro-Ala-Lys-(DNP)-OH as substrate after 20 mins by fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant TACE-mediated amyloid beta hydrolysis after 5 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP1-mediated amyloid beta hydrolysis using DNP-Pro-Cha-Gly- Cys(Me)-His-Ala- Lys(n-Me-Abz)-NH2 as substrate after 40...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetCollagenase 3(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP13-mediated amyloid beta hydrolysis after 10 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005646(CHEMBL3235419)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005645(CHEMBL3235418)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1M34PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
INSERM

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)copy SMILEScopy InChI
Affinity DataEC50:  530nMAssay Description:Induction of human recombinant IDE-mediated insulin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysisMore data for this Ligand-Target Pair