In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q29027TTPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q29027TTPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human BACE1 proteolytic activityMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Affinity DataIC50: 19.9nMAssay Description:Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of BACE1 expressed in HEK293T cells co-transfected APP with NFEV mutation at proteolytic site by sAPP_NF cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human BACE1 expressed in CHO cells co-transfected with human APP with Swedish mutation assessed as amyloid beta1-40 secreti...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q29027TTPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q29027TTPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Beijing Institute of Pharmacology and Toxicology
Curated by ChEMBL
Affinity DataIC50: 757nMAssay Description:Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 days by thioflavin T fluorescence...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assayMore data for this Ligand-Target Pair